PMID- 15301865
OWN - NLM
STAT- MEDLINE
DCOM- 20050214
LR  - 20221207
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 65
IP  - 7
DP  - 2004 Jul
TI  - Persistence of hepatitis C virus in a white population: associations with human 
      leukocyte antigen class 1.
PG  - 745-51
AB  - The aim of this study was to define novel associations between human leukocyte 
      antigen (HLA) class 1 alleles and persistence or clearance of the hepatitis C 
      virus (HCV) in a white population. All individuals in the study were seropositive 
      for anti-HCV antibodies. Viral status was determined by the Roche HCV Amplicor 
      test. HLA-A, -B, -C allelic group profile was molecularly defined by reverse line 
      probe hybridization. The strongest individual allelic group associations with 
      persistent HCV infection were HLA A*11 (p = 0.044) and Cw*04 (p = 0.006). 
      However, only the HLA C*04 association survived correction for multiple 
      comparisons. Further analysis of alleles in linkage with HLA Cw*04 revealed that 
      the haplotype HLA A*11, Cw*04 was present in 11 individuals, 10 of whom were 
      viremic (p = 0.05). No gene dosage effect was observed. No association between 
      HLA class 1 allelic groups and aviremia and virus load was evident in this white 
      population. HLA B*44 is associated with low virus load in human immunodeficiency 
      virus disease, but this association was not evident in this HCV-infected 
      population. Novel HLA class 1 alleles associated with persistence of HCV have 
      been identified.
FAU - Fanning, Liam J
AU  - Fanning LJ
AD  - Hepatitis C Unit, Department of Medicine, Clinical Sciences Building, Cork 
      University Hospital, National University of Ireland, Cork, Ireland. 
      1.fanning@ucc.ie
FAU - Kenny-Walsh, Elizabeth
AU  - Kenny-Walsh E
FAU - Shanahan, Fergus
AU  - Shanahan F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-C Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - DNA/genetics/isolation & purification
MH  - Data Interpretation, Statistical
MH  - Female
MH  - Gene Frequency/genetics
MH  - Genotype
MH  - HLA-A Antigens/genetics
MH  - HLA-B Antigens/genetics
MH  - HLA-C Antigens/genetics
MH  - Haplotypes/genetics
MH  - Hepacivirus/genetics/immunology
MH  - Hepatitis C, Chronic/blood/*genetics/immunology
MH  - Heterozygote
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Homozygote
MH  - Humans
MH  - Ireland
MH  - Male
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Genetic/*genetics
MH  - Viral Load
MH  - White People/*genetics
EDAT- 2004/08/11 05:00
MHDA- 2005/02/16 09:00
CRDT- 2004/08/11 05:00
PHST- 2003/12/30 00:00 [received]
PHST- 2004/08/11 05:00 [pubmed]
PHST- 2005/02/16 09:00 [medline]
PHST- 2004/08/11 05:00 [entrez]
AID - S0198885904001119 [pii]
AID - 10.1016/j.humimm.2004.05.001 [doi]
PST - ppublish
SO  - Hum Immunol. 2004 Jul;65(7):745-51. doi: 10.1016/j.humimm.2004.05.001.