PMID- 15301921
OWN - NLM
STAT- MEDLINE
DCOM- 20050304
LR  - 20151119
IS  - 0091-3057 (Print)
IS  - 0091-3057 (Linking)
VI  - 78
IP  - 4
DP  - 2004 Aug
TI  - Gender-related response in open-field activity following developmental nicotine 
      exposure in rats.
PG  - 675-81
AB  - Smoking during pregnancy may lead to low birthweight and behavioral alterations 
      in the offspring. In this study, the effects of developmental nicotine exposure 
      on the somatic growth of the offspring and the behavioral performance in the 
      open-field test were examined. Sprague-Dawley female rats were implanted with 
      nicotine (35 mg for 21-day time release; NIC 35) or placebo pellets on 
      gestational day (GD) 8 (postblastocyst implantation). A normal control group with 
      no pellet implant was also included. There was a significantly higher maternal 
      weight gain in the placebo group possibly due to a larger litter size. However, 
      there were no significant differences in body weights among all three treatment 
      groups for male and female offspring. The amount of activity, measured by the 
      total number of crossings in the open-field test, indicated a gender difference 
      in baseline level and pattern of ambulatory activity, with less activity (lower 
      number of crossings) in male offspring and an increase in the activity of the 
      female offspring as a function of testing day. The increase in the ambulatory 
      activity of the female offspring was observed in the placebo and normal, but not 
      the NIC 35 group suggesting that developmental nicotine exposure interferes with 
      open-field activity, and this behavioral alteration is gender related.
CI  - Copyright 2004 Elsevier Inc.
FAU - Romero, Roland D
AU  - Romero RD
AD  - Department of Human Anatomy and Medical Neurobiology, College of Medicine, The 
      Texas A&M University System Health Science Center, 142E Reynolds Medical 
      Building, College Station, TX 77843-1114, USA.
FAU - Chen, Wei-Jung A
AU  - Chen WJ
LA  - eng
GR  - NS39899/NS/NINDS NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 0 (Nicotinic Agonists)
RN  - 6M3C89ZY6R (Nicotine)
SB  - IM
MH  - Animals
MH  - Female
MH  - Growth/drug effects
MH  - Litter Size
MH  - Male
MH  - Motor Activity/*drug effects
MH  - Nicotine/*pharmacology
MH  - Nicotinic Agonists/*pharmacology
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Sex Characteristics
MH  - Weight Gain/drug effects
EDAT- 2004/08/11 05:00
MHDA- 2005/03/05 09:00
CRDT- 2004/08/11 05:00
PHST- 2004/02/19 00:00 [received]
PHST- 2004/04/20 00:00 [revised]
PHST- 2004/04/21 00:00 [accepted]
PHST- 2004/08/11 05:00 [pubmed]
PHST- 2005/03/05 09:00 [medline]
PHST- 2004/08/11 05:00 [entrez]
AID - S0091305704001911 [pii]
AID - 10.1016/j.pbb.2004.04.033 [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 2004 Aug;78(4):675-81. doi: 10.1016/j.pbb.2004.04.033.