PMID- 15301973
OWN - NLM
STAT- MEDLINE
DCOM- 20041130
LR  - 20061115
IS  - 0001-706X (Print)
IS  - 0001-706X (Linking)
VI  - 92
IP  - 1
DP  - 2004 Sep
TI  - The secretion of acute phase proteins and inflammatory cytokines during 
      Trypanosoma congolense infection is not affected by the absence of the TNF-alpha 
      gene.
PG  - 35-42
AB  - Tumor necrosis factor-alpha (TNF-alpha) plays a role in the host's defence 
      against infections with African trypanosomes. It helps to control the blood 
      stream form of the parasite and in Trypanosoma congolense infections, it also 
      prolongs survival. The mechanisms by which this cytokine can influence 
      parasitemia and survival are unknown. Therefore, the levels of acute phase 
      proteins and other inflammatory cytokines were monitored in trypano-tolerant 
      wild-type and TNF-alpha-deficient mice during a T. congolense infection. The 
      titres of ceruloplasmin (CP), alpha1-acid glycoprotein (AGP) and serum amyloid P 
      (SAP) increased and reached their peaks at 11 days post-infection, when the first 
      peak of parasitemia was observed. No significant differences were observed in the 
      acute phase protein profiles between the two mouse strains. Also the profiles of 
      serum titres of IFN-gamma, IL-1alpha, IL-6 and IL-10 were not significantly 
      different. Our present results indicate that acute phase protein and cytokine 
      responses can be induced in the absence of TNF-alpha during a T. congolense 
      infection in mice, and that the susceptibility of the TNF-alpha-deficient mice is 
      not due to modulation of expression of these molecules.
FAU - Kitani, Hiroshi
AU  - Kitani H
AD  - International livestock Research Institute, Genetic Resistance to Disease, P.O. 
      Box 30709, Nairobi, Kenya.
FAU - Yagi, Yukio
AU  - Yagi Y
FAU - Naessens, Jan
AU  - Naessens J
FAU - Sekikawa, Kenji
AU  - Sekikawa K
FAU - Iraqi, Fuad
AU  - Iraqi F
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Acta Trop
JT  - Acta tropica
JID - 0370374
RN  - 0 (Acute-Phase Proteins)
RN  - 0 (Cytokines)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Acute-Phase Proteins/*immunology
MH  - Animals
MH  - Cytokines/*immunology
MH  - Disease Susceptibility
MH  - Mice
MH  - *Trypanosoma congolense
MH  - Trypanosomiasis, African/genetics/*immunology
MH  - Tumor Necrosis Factor-alpha/*genetics/immunology
EDAT- 2004/08/11 05:00
MHDA- 2004/12/16 09:00
CRDT- 2004/08/11 05:00
PHST- 2004/02/04 00:00 [received]
PHST- 2004/05/18 00:00 [revised]
PHST- 2004/05/27 00:00 [accepted]
PHST- 2004/08/11 05:00 [pubmed]
PHST- 2004/12/16 09:00 [medline]
PHST- 2004/08/11 05:00 [entrez]
AID - S0001706X04001147 [pii]
AID - 10.1016/j.actatropica.2004.05.013 [doi]
PST - ppublish
SO  - Acta Trop. 2004 Sep;92(1):35-42. doi: 10.1016/j.actatropica.2004.05.013.