PMID- 15302103
OWN - NLM
STAT- MEDLINE
DCOM- 20050118
LR  - 20220409
IS  - 0195-668X (Print)
IS  - 0195-668X (Linking)
VI  - 25
IP  - 16
DP  - 2004 Aug
TI  - Association of RANTES G-403A gene polymorphism with increased risk of coronary 
      arteriosclerosis.
PG  - 1438-46
AB  - AIMS: Polymorphisms in the RANTES (G-403A), monocyte chemoattractant protein-1 
      (MCP-1; A-2518G), stromal cell-derived factor-1beta (SDF-1beta; G801A), and C-C 
      chemokine receptor-5 (CCR5; Delta32) genes have been associated with functional 
      effects. These chemokines have been implicated in leucocyte recruitment to 
      arterial lesions. In a case-control study, we explored relations between these 
      polymorphisms and coronary artery disease (CAD), with respect to angiographic 
      abnormalities and acute coronary syndromes (ACS). METHODS AND RESULTS: The 
      LUdwigshafen Risk and Cardiovascular health (LURIC) cohort was genotyped by 
      RFLP-PCR. Based on coronary angiography, individuals were sub-divided into CAD 
      cases (n = 2694) and controls (n = 530). RANTES-403 genotype frequencies were 
      significantly different in cases and controls (chi2 = 4.17, p = 0.041), as were A 
      allele carrier frequencies (36.01% vs. 30.19%, OR = 1.30 [95%-CI = 1.06-1.60], p 
      = 0.010). By multivariate analysis, RANTES A-403 retained significant association 
      with CAD (chi2 = 8.40, p = 0.0038). RANTES A-403 was associated with increased 
      ACS prevalence (OR = 1.36 [95%-CI = 1.08-1.71], p = 0.0073). MCP-1 G-2518, 
      SDF-1beta A801, and CCR5 Delta32 were not associated with CAD. CONCLUSIONS: 
      RANTES A-403 was associated with CAD independently from conventional risk factors 
      and CRP or fibrinogen as inflammatory biomarkers. The association was enhanced in 
      smokers and ACS, conditions where platelet activation and inflammation 
      predominate. RANTES A-403 may increase genetic susceptibility to CAD.
FAU - Simeoni, Eleonora
AU  - Simeoni E
AD  - Division of Cardiology, University of Lausanne, Switzerland.
FAU - Winkelmann, Bernhard R
AU  - Winkelmann BR
FAU - Hoffmann, Michael M
AU  - Hoffmann MM
FAU - Fleury, Sylvain
AU  - Fleury S
FAU - Ruiz, Juan
AU  - Ruiz J
FAU - Kappenberger, Lukas
AU  - Kappenberger L
FAU - Marz, Winfried
AU  - Marz W
FAU - Vassalli, Giuseppe
AU  - Vassalli G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Eur Heart J
JT  - European heart journal
JID - 8006263
RN  - 0 (Chemokine CCL5)
SB  - IM
CIN - Eur Heart J. 2004 Aug;25(16):1378-81. PMID: 15321696
MH  - Case-Control Studies
MH  - Chemokine CCL5/*genetics
MH  - Coronary Artery Disease/*genetics
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Genetic/*genetics
MH  - Risk Factors
EDAT- 2004/08/11 05:00
MHDA- 2005/01/19 09:00
CRDT- 2004/08/11 05:00
PHST- 2003/11/27 00:00 [received]
PHST- 2004/04/30 00:00 [revised]
PHST- 2004/05/05 00:00 [accepted]
PHST- 2004/08/11 05:00 [pubmed]
PHST- 2005/01/19 09:00 [medline]
PHST- 2004/08/11 05:00 [entrez]
AID - S0195668X04003148 [pii]
AID - 10.1016/j.ehj.2004.05.005 [doi]
PST - ppublish
SO  - Eur Heart J. 2004 Aug;25(16):1438-46. doi: 10.1016/j.ehj.2004.05.005.