PMID- 15302957
OWN - NLM
STAT- MEDLINE
DCOM- 20041012
LR  - 20200303
IS  - 0022-1317 (Print)
IS  - 0022-1317 (Linking)
VI  - 85
IP  - Pt 9
DP  - 2004 Sep
TI  - Transcriptional downregulation of DC-SIGN in human herpesvirus 6-infected 
      dendritic cells.
PG  - 2639-2642
LID - 10.1099/vir.0.80095-0 [doi]
AB  - DC-SIGN expressed on dendritic cells (DCs) efficiently binds and transmits 
      various pathogens, including human immunodeficiency virus, to lymphoid tissues 
      and permissive cells. Consequently, alteration of DC-SIGN expression may affect 
      susceptibility and resistance to pathogens. The present study shows that 
      infection with human herpesvirus 6 (HHV-6) induces downregulation of DC-SIGN 
      expression on immature DCs. Expression levels of DC-SIGN mRNA and intracellular 
      protein appeared to decrease following infection with HHV-6, indicating that 
      downregulation of surface DC-SIGN occurs at the transcriptional level. 
      Downregulation of DC-SIGN was not induced by inoculation of UV-inactivated HHV-6 
      or culture supernatant of HHV-6-infected DCs, indicating that replication of 
      HHV-6 in DCs is required for downregulation of DC-SIGN. The present study 
      demonstrates for the first time that expression of DC-SIGN is altered at the 
      transcriptional level by virus infection.
FAU - Niiya, Hironari
AU  - Niiya H
AD  - First Department of Internal Medicine and Department of Dermatology, Ehime 
      University School of Medicine, Shigenobu, Ehime 791-0295, Japan.
FAU - Azuma, Taichi
AU  - Azuma T
AD  - First Department of Internal Medicine and Department of Dermatology, Ehime 
      University School of Medicine, Shigenobu, Ehime 791-0295, Japan.
FAU - Jin, Lei
AU  - Jin L
AD  - First Department of Internal Medicine and Department of Dermatology, Ehime 
      University School of Medicine, Shigenobu, Ehime 791-0295, Japan.
FAU - Uchida, Naoyuki
AU  - Uchida N
AD  - First Department of Internal Medicine and Department of Dermatology, Ehime 
      University School of Medicine, Shigenobu, Ehime 791-0295, Japan.
FAU - Inoue, Atsushi
AU  - Inoue A
AD  - First Department of Internal Medicine and Department of Dermatology, Ehime 
      University School of Medicine, Shigenobu, Ehime 791-0295, Japan.
FAU - Hasegawa, Hitoshi
AU  - Hasegawa H
AD  - First Department of Internal Medicine and Department of Dermatology, Ehime 
      University School of Medicine, Shigenobu, Ehime 791-0295, Japan.
FAU - Fujita, Shigeru
AU  - Fujita S
AD  - First Department of Internal Medicine and Department of Dermatology, Ehime 
      University School of Medicine, Shigenobu, Ehime 791-0295, Japan.
FAU - Tohyama, Mikiko
AU  - Tohyama M
AD  - First Department of Internal Medicine and Department of Dermatology, Ehime 
      University School of Medicine, Shigenobu, Ehime 791-0295, Japan.
FAU - Hashimoto, Koji
AU  - Hashimoto K
AD  - First Department of Internal Medicine and Department of Dermatology, Ehime 
      University School of Medicine, Shigenobu, Ehime 791-0295, Japan.
FAU - Yasukawa, Masaki
AU  - Yasukawa M
AD  - First Department of Internal Medicine and Department of Dermatology, Ehime 
      University School of Medicine, Shigenobu, Ehime 791-0295, Japan.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - J Gen Virol
JT  - The Journal of general virology
JID - 0077340
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (DC-specific ICAM-3 grabbing nonintegrin)
RN  - 0 (Lectins, C-Type)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Receptors, Virus)
SB  - IM
MH  - Cell Adhesion Molecules/genetics/*metabolism
MH  - Dendritic Cells/metabolism/*virology
MH  - Down-Regulation
MH  - Herpesvirus 6, Human/*physiology/radiation effects
MH  - Humans
MH  - Lectins, C-Type/genetics/*metabolism
MH  - RNA, Messenger/analysis
MH  - Receptors, Cell Surface/genetics/*metabolism
MH  - Receptors, Virus/genetics/*metabolism
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Transcription, Genetic
MH  - Ultraviolet Rays
MH  - Virus Replication
EDAT- 2004/08/11 05:00
MHDA- 2004/10/13 09:00
CRDT- 2004/08/11 05:00
PHST- 2004/08/11 05:00 [pubmed]
PHST- 2004/10/13 09:00 [medline]
PHST- 2004/08/11 05:00 [entrez]
AID - 10.1099/vir.0.80095-0 [doi]
PST - ppublish
SO  - J Gen Virol. 2004 Sep;85(Pt 9):2639-2642. doi: 10.1099/vir.0.80095-0.