PMID- 15303275
OWN - NLM
STAT- MEDLINE
DCOM- 20040910
LR  - 20190612
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 320
IP  - 4
DP  - 2004 Aug 6
TI  - The 10 C-terminal residues of HTLV-I protease are not necessary for enzymatic 
      activity.
PG  - 1306-8
AB  - Sequence alignment of human T-lymphotropic virus type I (HTLV-I) protease and 
      other retroviral proteases reveals that the leukemia virus proteases contain 
      residues at the C-terminus that are absent in the other proteases. We have 
      prepared a mutant of HTLV-I protease that does not contain the 10 C-terminal 
      residues and demonstrated that the catalytic efficiency of cleavage of a peptide 
      substrate is unaffected.
FAU - Herger, Bryan E
AU  - Herger BE
AD  - Georgia Institute of Technology, School of Chemistry and Biochemistry, Atlanta 
      30332-0400, USA.
FAU - Mariani, Victoria L
AU  - Mariani VL
FAU - Dennison, KellyJ
AU  - Dennison K
FAU - Shuker, Suzanne B
AU  - Shuker SB
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Amino Acids)
RN  - 0 (Recombinant Proteins)
RN  - EC 3.4.- (Endopeptidases)
SB  - IM
MH  - Amino Acid Sequence
MH  - Amino Acid Substitution
MH  - Amino Acids/*chemistry
MH  - Binding Sites
MH  - Computer Simulation
MH  - Endopeptidases/*chemistry/genetics/*metabolism
MH  - Enzyme Activation
MH  - Escherichia coli/enzymology/genetics
MH  - Human T-lymphotropic virus 1/*enzymology/genetics
MH  - *Models, Molecular
MH  - Molecular Sequence Data
MH  - Protein Binding
MH  - Protein Conformation
MH  - Recombinant Proteins/chemistry/metabolism
MH  - Sequence Homology, Amino Acid
MH  - Structure-Activity Relationship
EDAT- 2004/08/12 05:00
MHDA- 2004/09/11 05:00
CRDT- 2004/08/12 05:00
PHST- 2004/08/12 05:00 [pubmed]
PHST- 2004/09/11 05:00 [medline]
PHST- 2004/08/12 05:00 [entrez]
AID - S0006-291X(04)01344-0 [pii]
AID - 10.1016/j.bbrc.2004.06.087 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2004 Aug 6;320(4):1306-8. doi: 
      10.1016/j.bbrc.2004.06.087.