PMID- 15303577
OWN - NLM
STAT- MEDLINE
DCOM- 20041123
LR  - 20170214
IS  - 0961-2033 (Print)
IS  - 0961-2033 (Linking)
VI  - 13
IP  - 6
DP  - 2004
TI  - IVIG treatment for progressive stroke in the primary antiphospholipid antibody 
      syndrome.
PG  - 478-80
AB  - A 32-year old woman with antiphospholipid antibody syndrome (APS) developed 
      severe thrombocytopenia, elevated liver enzymes and progressive cerebral 
      thrombosis a few days after preterm delivery by caesarean section. Her condition 
      deteriorated despite treatment with low dose aspirin, anticoagulation by heparin 
      and iv glucocorticoid administration. Intravenous immunoglobulin (IVIG) on three 
      consecutive days was followed by rapid resolution of her neurological impairment 
      and increasing platelets counts. The temporal association between IVIG and 
      reversal of both neurological impairment and platelet number strongly indicates a 
      specific effect of IVIG administration in this condition. It is proposed that 
      IVIG therapy is considered as a therapeutic option in APS patients with 
      progressive cerebral infarction despite optimal use of anticoagulant and 
      immunomodulating agents.
FAU - Horn, H C
AU  - Horn HC
AD  - Department of Internal Medicine C, Section of Rheumatology, Odense University 
      Hospital, Denmark. hc.horn@dadlnet.dk
FAU - Grau, K
AU  - Grau K
FAU - Junker, P
AU  - Junker P
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Lupus
JT  - Lupus
JID - 9204265
RN  - 0 (Immunoglobulins, Intravenous)
SB  - IM
CIN - Lupus. 2005;14(5):409-10. PMID: 15934444
MH  - Adult
MH  - Antiphospholipid Syndrome/*complications/drug therapy
MH  - Female
MH  - Humans
MH  - Immunoglobulins, Intravenous/*therapeutic use
MH  - Pregnancy
MH  - Stroke/*drug therapy/etiology
EDAT- 2004/08/12 05:00
MHDA- 2004/12/16 09:00
CRDT- 2004/08/12 05:00
PHST- 2004/08/12 05:00 [pubmed]
PHST- 2004/12/16 09:00 [medline]
PHST- 2004/08/12 05:00 [entrez]
AID - 10.1191/0961203303lu1035cr [doi]
PST - ppublish
SO  - Lupus. 2004;13(6):478-80. doi: 10.1191/0961203303lu1035cr.