PMID- 15304960
OWN - NLM
STAT- MEDLINE
DCOM- 20041026
LR  - 20190513
IS  - 0449-3060 (Print)
IS  - 0449-3060 (Linking)
VI  - 45
IP  - 2
DP  - 2004 Jun
TI  - Chromosomal aberrations in lymphocytes of lung cancer patients treated with 
      carbon ions.
PG  - 195-9
AB  - The purpose of this study is to investigate the normal tissue damage caused by 
      carbon-ion therapy. We measured chromosomal aberrations in peripheral blood 
      lymphocytes before, during, and after radiotherapy, using the techniques of 
      fluorescence in situ hybridization (FISH) and chemically induced premature 
      chromosome condensation (PCC). Twenty-two lung cancer patients treated at HIMAC 
      (Heavy Ion Medical Accelerator in Chiba) entered the study and signed an informed 
      consent. Frequencies of lymphocytes with chromosomal aberrations at the end of 
      carbon-ion therapy varied among the patients. This frequency was significantly 
      correlated to the radiation field size and weakly correlated to the counts of 
      white blood cells and lymphocytes during the treatment. As a result, we have 
      found that chromosomal aberrations in peripheral blood lymphocytes from patients 
      treated for lung cancer by carbon-ions were dependent on target volume, possibly 
      reflecting the increased involvement of lymph nodes in the target field.
FAU - Lee, Ryonfa
AU  - Lee R
AD  - Heavy-Ion Radiobiology Research Group, National Institute of Radiological 
      Sciences, Chiba, Japan.
FAU - Yamada, Shigeru
AU  - Yamada S
FAU - Yamamoto, Naoyoshi
AU  - Yamamoto N
FAU - Miyamoto, Tadaaki
AU  - Miyamoto T
FAU - Ando, Koichi
AU  - Ando K
FAU - Durante, Marco
AU  - Durante M
FAU - Tsujii, Hirohiko
AU  - Tsujii H
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Radiat Res
JT  - Journal of radiation research
JID - 0376611
RN  - 0 (Carbon Isotopes)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Carbon Isotopes/adverse effects/therapeutic use
MH  - Chromosome Aberrations/*radiation effects
MH  - Chromosomes, Human/*radiation effects/ultrastructure
MH  - Female
MH  - Heavy Ion Radiotherapy
MH  - Heavy Ions/*adverse effects
MH  - Humans
MH  - Leukocyte Count
MH  - Lung Neoplasms/blood/complications/pathology/*radiotherapy
MH  - Lymphocytes/*radiation effects/ultrastructure
MH  - Male
MH  - Middle Aged
MH  - Radiation Injuries/*blood/etiology/*pathology
MH  - Radiotherapy/adverse effects
EDAT- 2004/08/12 05:00
MHDA- 2004/10/27 09:00
CRDT- 2004/08/12 05:00
PHST- 2004/08/12 05:00 [pubmed]
PHST- 2004/10/27 09:00 [medline]
PHST- 2004/08/12 05:00 [entrez]
AID - JST.JSTAGE/jrr/45.195 [pii]
AID - 10.1269/jrr.45.195 [doi]
PST - ppublish
SO  - J Radiat Res. 2004 Jun;45(2):195-9. doi: 10.1269/jrr.45.195.