PMID- 15307911
OWN - NLM
STAT- MEDLINE
DCOM- 20040915
LR  - 20181113
IS  - 0889-2229 (Print)
IS  - 1931-8405 (Electronic)
IS  - 0889-2229 (Linking)
VI  - 20
IP  - 7
DP  - 2004 Jul
TI  - Human leukocyte antigen (HLA) B*18 and protection against mother-to-child HIV 
      type 1 transmission.
PG  - 692-7
AB  - Human leukocyte antigen (HLA) molecules regulate the cellular immune system and 
      may be determinants of infant susceptibility to human immunodeficiency virus type 
      1 (HIV-1) infection. Molecular HLA typing for class I alleles was performed on 
      infants followed in a Kenyan perinatal cohort. Early HIV-1 infection status was 
      defined as infection occurring at birth or month 1, while late infection via 
      breast milk was defined as first detection of HIV-1 after 1 month of age. 
      Likelihood ratio tests based on a proportional hazards model adjusting for 
      maternal CD4 T cell count and HIV-1 viral load at 32 weeks of gestation were used 
      to test associations between infant allelic variation and incident HIV-1 
      infection. Among 433 infants, 76 (18%) were HIV-1 infected during 12 months of 
      follow-up. HLA B*18 was associated with a significantly lower risk of early HIV-1 
      transmission [relative risk (RR) = 0.26; 95% confidence interval (CI) 0.04-0.82], 
      and none of the 24 breastfeeding infants expressing HLA B*18 who were uninfected 
      at month 1 acquired HIV-1 late via breast milk. We observed a trend toward 
      increased early HIV-1 acquisition for infants presenting HLA A*29 (RR = 2.0; 95% 
      CI 1.0-3.8) and increased late HIV-1 acquisition via breast milk for both Cw*07 
      and Cw*08 (RR = 4.0; 95% CI 1.0-17.8 and RR = 7.2; 95% CI 1.2-37.3, 
      respectively). HLA B*18 may protect breast-feeding infants against both early and 
      late HIV-1 acquisition, a finding that could have implications for the design and 
      monitoring of HIV-1 vaccines targeting cellular immune responses against HIV-1.
FAU - Farquhar, Carey
AU  - Farquhar C
AD  - Department of Medicine, University of Washington, Seattle, Washington 98104, USA. 
      cfarq@u.washington.edu
FAU - Rowland-Jones, Sarah
AU  - Rowland-Jones S
FAU - Mbori-Ngacha, Dorothy
AU  - Mbori-Ngacha D
FAU - Redman, Mary
AU  - Redman M
FAU - Lohman, Barbara
AU  - Lohman B
FAU - Slyker, Jennifer
AU  - Slyker J
FAU - Otieno, Phelgona
AU  - Otieno P
FAU - Obimbo, Elizabeth
AU  - Obimbo E
FAU - Rostron, Timothy
AU  - Rostron T
FAU - Ochieng, James
AU  - Ochieng J
FAU - Oyugi, Julius
AU  - Oyugi J
FAU - Bosire, Rose
AU  - Bosire R
FAU - John-Stewart, Grace
AU  - John-Stewart G
LA  - eng
GR  - K23 HD-41879/HD/NICHD NIH HHS/United States
GR  - D43-TW00007/TW/FIC NIH HHS/United States
GR  - D43 TW000007/TW/FIC NIH HHS/United States
GR  - R01 HD023412-19/HD/NICHD NIH HHS/United States
GR  - R01 HD023412/HD/NICHD NIH HHS/United States
GR  - P30 AI027757-14/AI/NIAID NIH HHS/United States
GR  - P30 AI027757/AI/NIAID NIH HHS/United States
GR  - K23 HD041879/HD/NICHD NIH HHS/United States
GR  - R01 HD-23412/HD/NICHD NIH HHS/United States
GR  - K01 AI087369/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - AIDS Res Hum Retroviruses
JT  - AIDS research and human retroviruses
JID - 8709376
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-B18 Antigen)
RN  - 0 (HLA-C Antigens)
SB  - IM
MH  - Acquired Immunodeficiency Syndrome/*immunology/prevention & control
MH  - CD4 Lymphocyte Count
MH  - Female
MH  - HLA-A Antigens/immunology
MH  - HLA-B Antigens/*immunology
MH  - HLA-B18 Antigen
MH  - HLA-C Antigens/immunology
MH  - Histocompatibility Testing
MH  - Humans
MH  - Infectious Disease Transmission, Vertical/*prevention & control
MH  - Pregnancy
MH  - Pregnancy Complications, Infectious/*virology
MH  - Viral Load
PMC - PMC3380108
MID - NIHMS359248
EDAT- 2004/08/17 10:00
MHDA- 2004/09/16 05:00
PMCR- 2012/06/20
CRDT- 2004/08/17 10:00
PHST- 2004/08/17 10:00 [pubmed]
PHST- 2004/09/16 05:00 [medline]
PHST- 2004/08/17 10:00 [entrez]
PHST- 2012/06/20 00:00 [pmc-release]
AID - 10.1089/0889222041524616 [doi]
PST - ppublish
SO  - AIDS Res Hum Retroviruses. 2004 Jul;20(7):692-7. doi: 10.1089/0889222041524616.