PMID- 15307945
OWN - NLM
STAT- MEDLINE
DCOM- 20050216
LR  - 20220321
IS  - 1050-7256 (Print)
IS  - 1050-7256 (Linking)
VI  - 14
IP  - 7
DP  - 2004 Jul
TI  - Familial occurrence of subacute thyroiditis associated with human leukocyte 
      antigen-B35.
PG  - 544-7
AB  - Subacute thyroiditis (SAT) is a spontaneously remitting inflammatory disorder of 
      the thyroid, associated with human leukocyte antigen (HLA)-B35, and may be 
      virally induced in genetically predisposed individuals. A 57-year-old Caucasian 
      man presented with symptoms of hyperthyroidism as well as enlargement and 
      tenderness of the thyroid. The patient had an elevated erythrocyte sedimentation 
      rate, low thyrotropin (TSH) and elevated thyroxine and triiodothyroinine levels 
      with suppressed 131I thyroidal uptake. He was diagnosed to have SAT. In the 
      patient's family three sisters and one brother also had had SAT, as probably did 
      the deceased father. Because of the familial occurrence HLA-typing was performed. 
      All affected family members were heterozygous for HLA-B35. The family members 
      lived more than 50 miles apart in different regions of The Netherlands and had 
      SAT at different time points between 1986 and 2002, which in combination with 
      HLA-B35 seems to highlight the importance of genetic influences as a risk factor 
      for the development of SAT in this family. In conclusion, the case described here 
      represents the second familial incidence and largest family reported so far with 
      occurrence of SAT in association with HLA-B35.
FAU - Kramer, Andrea B
AU  - Kramer AB
AD  - Department of Endocrinology, and Department of Pathology and Laboratory Medicine, 
      University Hospital Groningen, The Netherlands.
FAU - Roozendaal, Caroline
AU  - Roozendaal C
FAU - Dullaart, Robin P F
AU  - Dullaart RP
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Thyroid
JT  - Thyroid : official journal of the American Thyroid Association
JID - 9104317
RN  - 0 (HLA-B35 Antigen)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Family Health
MH  - Female
MH  - HLA-B35 Antigen/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pedigree
MH  - Thyroiditis, Subacute/*genetics
EDAT- 2004/08/17 10:00
MHDA- 2005/02/17 09:00
CRDT- 2004/08/17 10:00
PHST- 2004/08/17 10:00 [pubmed]
PHST- 2005/02/17 09:00 [medline]
PHST- 2004/08/17 10:00 [entrez]
AID - 10.1089/1050725041517048 [doi]
PST - ppublish
SO  - Thyroid. 2004 Jul;14(7):544-7. doi: 10.1089/1050725041517048.