PMID- 15308783
OWN - NLM
STAT- MEDLINE
DCOM- 20050322
LR  - 20220311
IS  - 1524-4628 (Electronic)
IS  - 0039-2499 (Linking)
VI  - 35
IP  - 10
DP  - 2004 Oct
TI  - Proinflammatory genetic profiles in subjects with history of ischemic stroke.
PG  - 2270-5
AB  - BACKGROUND AND PURPOSE: Proinflammatory genetic profiles, resulting from the 
      combination of single nucleotide polymorphisms in genes encoding inflammatory 
      molecules, may contribute to the development and progression of cardiovascular 
      diseases. We evaluated the association between history of ischemic stroke and 
      genetic profiles determined by the synergistic effects of polymorphisms in genes 
      encoding prototypical inflammatory proteins. METHODS: The study included 237 
      individuals with history of ischemic stroke and 223 age-matched and 
      gender-matched controls. The polymorphisms of the C-reactive protein (CRP), 
      interleukin-6 (IL-6), macrophage migration inhibitory factor (MIF), monocyte 
      chemoattractant protein-1 (MCP-1), intercellular adhesion molecule-1 (ICAM-1), 
      E-selectin (E-sel), and matrix metalloproteinase-3 (MMP-3) genes were studied. 
      RESULTS: IL-6 GG, IL-6 GC, MCP-1 GG, ICAM-1 EE, E-sel AA, and MMP-3 5A5A 
      genotypes were significantly and independently associated with stroke history. 
      The odds of stroke increased with the number of high-risk genotypes: carrying 1 
      proinflammatory gene variant conferred a risk of 3.3 (1.6 to 6.9), whereas 
      individuals concomitantly carrying 2 and 3 proinflammatory gene variants had 
      adjusted odds ratios of 21.0 (7.6 to 57.5) and 50.3 (10.2 to 248.1), 
      respectively. CONCLUSIONS: Proinflammatory genetic profiles are significantly 
      more common in subjects with stroke history. Synergistic effects between 
      proinflammatory genotypes might be potential markers for cerebrovascular 
      diseases.
FAU - Flex, Andrea
AU  - Flex A
AD  - Laboratory of Vascular Biology and Genetics, . Gemelli University Hospital, 
      Universita Cattolica del Sacro Cuore, School of Medicine, Rome, Italy.
FAU - Gaetani, Eleonora
AU  - Gaetani E
FAU - Papaleo, Pierangelo
AU  - Papaleo P
FAU - Straface, Giuseppe
AU  - Straface G
FAU - Proia, Anna S
AU  - Proia AS
FAU - Pecorini, Giovanni
AU  - Pecorini G
FAU - Tondi, Paolo
AU  - Tondi P
FAU - Pola, Paolo
AU  - Pola P
FAU - Pola, Roberto
AU  - Pola R
LA  - eng
PT  - Journal Article
DEP - 20040812
PL  - United States
TA  - Stroke
JT  - Stroke
JID - 0235266
RN  - 0 (Biomarkers)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (E-Selectin)
RN  - 0 (Immunologic Factors)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Interleukin-6)
RN  - 0 (Macrophage Migration-Inhibitory Factors)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Aged
MH  - Biomarkers/analysis
MH  - C-Reactive Protein/genetics
MH  - Case-Control Studies
MH  - Chemokine CCL2/genetics
MH  - E-Selectin/genetics
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Immunologic Factors/*genetics
MH  - Inflammation Mediators/analysis
MH  - Intercellular Adhesion Molecule-1/genetics
MH  - Interleukin-6/genetics
MH  - Macrophage Migration-Inhibitory Factors/genetics
MH  - Male
MH  - Matrix Metalloproteinase 3/genetics
MH  - Middle Aged
MH  - *Polymorphism, Genetic
MH  - Risk Factors
MH  - Stroke/epidemiology/*genetics/immunology
EDAT- 2004/08/17 10:00
MHDA- 2005/03/23 09:00
CRDT- 2004/08/17 10:00
PHST- 2004/08/17 10:00 [pubmed]
PHST- 2005/03/23 09:00 [medline]
PHST- 2004/08/17 10:00 [entrez]
AID - 01.STR.0000140740.19421.fe [pii]
AID - 10.1161/01.STR.0000140740.19421.fe [doi]
PST - ppublish
SO  - Stroke. 2004 Oct;35(10):2270-5. doi: 10.1161/01.STR.0000140740.19421.fe. Epub 
      2004 Aug 12.