PMID- 1530891
OWN - NLM
STAT- MEDLINE
DCOM- 19920211
LR  - 20151119
IS  - 0256-9574 (Print)
VI  - 81
IP  - 1
DP  - 1992 Jan 4
TI  - The influence of platelet-graft interaction on platelet survival in patients with 
      aortobifemoral Dacron grafts.
PG  - 27-31
AB  - In patients with arterial grafts, platelet consumption may be due either to 
      platelet interaction with the graft, and/or concomitant platelet consumption in 
      the rest of the arterial tree. This hypothesis was tested by quantifying the 
      kinetics and platelet-graft interaction of indium-111-labelled platelets with 
      double velour Dacron grafts in 13 patients with arterial insufficiency ascribed 
      to atherosclerosis. Mean platelet lifespan (MPLS), 149 +/- 46 hours, was 
      significantly shorter (P = 0.001) than normal. Labelled platelets were 
      transiently deposited onto the graft surfaces. Peak 111In deposition on the 
      grafts, 1.33 +/- 1.02% of injected labelled platelets, was reached at 70 +/- 33 
      hours. Thereafter the graft-platelet radioactivity decreased in parallel with 
      platelet radioactivity in the circulation. There was no statistical correlation 
      between MPLS and the factors known to be associated with graft platelet 
      deposition: graft size; peak graft radioactivity; and the time to attain peak 
      graft radioactivity. It is therefore concluded that in patients with arterial 
      disease requiring graft implantation, the observed increased platelet consumption 
      cannot only be ascribed to the interaction of platelets with the graft. 
      Concomitant atherosclerosis is probably the important modifier of platelet 
      consumption. The significant contribution of this factor to the shortening of the 
      MPLS should be taken into account when assessing, by measuring platelet lifespan, 
      the thrombogenicity of grafts.
FAU - Kotze, H F
AU  - Kotze HF
AD  - Department of Haematology, University of the Orange Free State, Bloemfontein.
FAU - Heyns, A D
AU  - Heyns AD
FAU - Nel, C J
AU  - Nel CJ
FAU - Roodt, J P
AU  - Roodt JP
FAU - Herbst, C P
AU  - Herbst CP
FAU - Badenhorst, P N
AU  - Badenhorst PN
FAU - Lotter, M G
AU  - Lotter MG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - South Africa
TA  - S Afr Med J
JT  - South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde
JID - 0404520
RN  - 0 (Indium Radioisotopes)
RN  - 0 (Polyethylene Terephthalates)
SB  - IM
MH  - Aged
MH  - Aorta/surgery
MH  - Blood Platelets/*physiology
MH  - Blood Vessel Prosthesis/*adverse effects
MH  - Cell Survival
MH  - Female
MH  - Femoral Artery/surgery
MH  - Graft Occlusion, Vascular
MH  - Humans
MH  - Indium Radioisotopes
MH  - Male
MH  - Middle Aged
MH  - Platelet Count
MH  - *Polyethylene Terephthalates
EDAT- 1992/01/04 00:00
MHDA- 1992/01/04 00:01
CRDT- 1992/01/04 00:00
PHST- 1992/01/04 00:00 [pubmed]
PHST- 1992/01/04 00:01 [medline]
PHST- 1992/01/04 00:00 [entrez]
PST - ppublish
SO  - S Afr Med J. 1992 Jan 4;81(1):27-31.