PMID- 15309700
OWN - NLM
STAT- MEDLINE
DCOM- 20050819
LR  - 20191108
IS  - 1071-9164 (Print)
IS  - 1071-9164 (Linking)
VI  - 10
IP  - 4
DP  - 2004 Aug
TI  - Plasma MMP-9 and MMP-2 following acute myocardial infarction in man: correlation 
      with echocardiographic and neurohumoral parameters of left ventricular 
      dysfunction.
PG  - 328-33
AB  - BACKGROUND: Left ventricular dilatation and elevated plasma natriuretic peptide 
      levels predict adverse prognosis and the development of congestive heart failure 
      after myocardial infarction. Altered matrix metalloproteinase (MMP) activity has 
      been implicated in the structural changes associated with development of heart 
      failure after myocardial injury. The aims of this study were to investigate 
      plasma MMP-2, MMP-9, and tissue inhibitor of metalloproteinase (TIMP)-1 
      concentrations following acute myocardial infarction and their relationships with 
      measures of left ventricular function. METHODS AND RESULTS: Plasma MMP-2, MMP-9, 
      TIMP-1, and N-terminal proBNP (N-BNP) were quantified on 5 consecutive days in 60 
      patients with acute myocardial infarction (39 anterior). N-BNP was measured on 
      day 3. Echocardiographic assessment of left ventricular wall motion index and 
      volumes was performed during admission and 6 weeks later. Plasma MMP-9 showed 
      peaks on days 1 and 4. MMP-2 levels, similar on each day, were higher after 
      inferior myocardial infarction. Plasma MMP-2 showed strong, inverse correlation 
      with left ventricular volumes during and after admission. Plasma MMP-9 correlated 
      directly with N-BNP (P=.022) and inversely with wall motion index during 
      admission (P=.05). TIMP-1 levels were higher after anterior (1269, 870-1466 
      ng/mL) compared with inferior (1183, 856-1419 ng/mL, P=.05) acute myocardial 
      infarction and fell from day 1 through 5 (P <.0005). CONCLUSION: Plasma MMP-9 
      concentration correlates with neurohormonal and echocardiographic measures of 
      left ventricular dysfunction after myocardial infarction. Higher left ventricular 
      volumes are associated with lower plasma MMP-2 concentrations. Circulating MMP 
      concentrations may provide insights into left ventricular remodeling after acute 
      myocardial infarction.
FAU - Squire, Iain B
AU  - Squire IB
AD  - Department of Medicine and Therapeutics, University of Leicester, Leicester, 
      United Kingdom.
FAU - Evans, Jon
AU  - Evans J
FAU - Ng, Leong L
AU  - Ng LL
FAU - Loftus, Ian M
AU  - Loftus IM
FAU - Thompson, Matt M
AU  - Thompson MM
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - J Card Fail
JT  - Journal of cardiac failure
JID - 9442138
RN  - 0 (Biomarkers)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Neurotransmitter Agents)
RN  - 0 (Peptide Fragments)
RN  - 0 (Tissue Inhibitor of Metalloproteinase-1)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
RN  - EC 3.4.24.24 (Matrix Metalloproteinase 2)
RN  - EC 3.4.24.35 (Matrix Metalloproteinase 9)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers/blood
MH  - Echocardiography
MH  - Female
MH  - Humans
MH  - Male
MH  - Matrix Metalloproteinase 2/*blood
MH  - Matrix Metalloproteinase 9/*blood
MH  - Middle Aged
MH  - Myocardial Infarction/*blood/diagnostic imaging/physiopathology
MH  - Natriuretic Peptide, Brain
MH  - Nerve Tissue Proteins/blood
MH  - Neurotransmitter Agents/blood
MH  - Peptide Fragments/blood
MH  - Statistics as Topic
MH  - Stroke Volume/physiology
MH  - Tissue Inhibitor of Metalloproteinase-1/blood
MH  - Ventricular Dysfunction, Left/blood/diagnostic imaging/physiopathology
EDAT- 2004/08/17 10:00
MHDA- 2005/08/20 09:00
CRDT- 2004/08/17 10:00
PHST- 2004/08/17 10:00 [pubmed]
PHST- 2005/08/20 09:00 [medline]
PHST- 2004/08/17 10:00 [entrez]
AID - S1071916403007991 [pii]
AID - 10.1016/j.cardfail.2003.11.003 [doi]
PST - ppublish
SO  - J Card Fail. 2004 Aug;10(4):328-33. doi: 10.1016/j.cardfail.2003.11.003.