PMID- 15309701
OWN - NLM
STAT- MEDLINE
DCOM- 20050819
LR  - 20191210
IS  - 1071-9164 (Print)
IS  - 1071-9164 (Linking)
VI  - 10
IP  - 4
DP  - 2004 Aug
TI  - Increased F2 isoprostane plasma levels in patients with congestive heart failure 
      are correlated with antioxidant status and disease severity.
PG  - 334-8
AB  - BACKGROUND: A growing body of evidence supports the pathophysiologic role of 
      oxidative stress and the protective role of naturally occurring antioxidants in 
      congestive heart failure (CHF). Circulating levels of a sensitive and specific 
      marker of lipid peroxidation and levels and activities of a broad spectrum of 
      essential antioxidant micronutrients, vitamins, and enzymes, however, have been 
      never simultaneously evaluated in well-characterized CHF patients. METHODS AND 
      RESULTS: Plasma levels of 8,12-isoprostane F(2alpha)-VI; vitamins A, C, and E; 
      uric acid; and five carotenoids as well as activities of plasma superoxide 
      dismutase and glutathione peroxidase were measured in 30 patients with class II 
      and III New York Heart Association (NYHA) CHF and in 30 controls. Ejection 
      fraction was measured in all patients. Significantly higher 8,12-isoprostane 
      F(2alpha)-VI levels and lower antioxidant levels and activities were found in CHF 
      patients in comparison to controls. Levels of 8,12-isoprostane F(2alpha)-VI were 
      higher in class III than in class II NYHA CHF patients (P=.0012), and inversely 
      correlated with ejection fraction; vitamins A, C, and E; uric acid; carotenoid 
      levels; and superoxide dismutase activity. CONCLUSION: There is an association 
      between increased lipid peroxidation and both antioxidant status and disease 
      severity in CHF in humans. These findings support the rationale for intervention 
      trials aiming at exploring beneficial effects of antioxidant micronutrients in 
      this disease.
FAU - Polidori, M Cristina
AU  - Polidori MC
AD  - Institute of Biochemistry and Molecular Biology I, Heinrich-Heine University, 
      Dusseldorf, Germany.
FAU - Pratico, Domenico
AU  - Pratico D
FAU - Savino, Ketty
AU  - Savino K
FAU - Rokach, Joshua
AU  - Rokach J
FAU - Stahl, Wilhelm
AU  - Stahl W
FAU - Mecocci, Patrizia
AU  - Mecocci P
LA  - eng
GR  - DK44730/DK/NIDDK NIH HHS/United States
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Card Fail
JT  - Journal of cardiac failure
JID - 9442138
RN  - 0 (8,12-iso-isoprostane F2alpha-VI)
RN  - 0 (Antioxidants)
RN  - 0 (Biomarkers)
RN  - 0 (F2-Isoprostanes)
RN  - 11103-57-4 (Vitamin A)
RN  - 1406-18-4 (Vitamin E)
RN  - 268B43MJ25 (Uric Acid)
RN  - 36-88-4 (Carotenoids)
RN  - B7IN85G1HY (Dinoprost)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - PQ6CK8PD0R (Ascorbic Acid)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Antioxidants/*metabolism
MH  - Ascorbic Acid/metabolism
MH  - Biomarkers/blood
MH  - Carotenoids/metabolism
MH  - Dinoprost/*analogs & derivatives/blood
MH  - F2-Isoprostanes/*blood
MH  - Female
MH  - Glutathione Peroxidase/blood
MH  - Heart Failure/*metabolism
MH  - Humans
MH  - Male
MH  - Severity of Illness Index
MH  - Statistics as Topic
MH  - Stroke Volume/physiology
MH  - Superoxide Dismutase/blood
MH  - Uric Acid/metabolism
MH  - Vitamin A/metabolism
MH  - Vitamin E/metabolism
EDAT- 2004/08/17 10:00
MHDA- 2005/08/20 09:00
CRDT- 2004/08/17 10:00
PHST- 2004/08/17 10:00 [pubmed]
PHST- 2005/08/20 09:00 [medline]
PHST- 2004/08/17 10:00 [entrez]
AID - S1071916403008005 [pii]
AID - 10.1016/j.cardfail.2003.11.004 [doi]
PST - ppublish
SO  - J Card Fail. 2004 Aug;10(4):334-8. doi: 10.1016/j.cardfail.2003.11.004.