PMID- 15309910
OWN - NLM
STAT- MEDLINE
DCOM- 20040902
LR  - 20220311
IS  - 0022-3085 (Print)
IS  - 0022-3085 (Linking)
VI  - 101
IP  - 2
DP  - 2004 Aug
TI  - Malignant progression in meningioma: documentation of a series and analysis of 
      cytogenetic findings.
PG  - 210-8
AB  - OBJECT: The malignant progression of benign tumors is well documented in gliomas 
      and other systemic lesions. It is also well known that some meningiomas become 
      progressively aggressive despite their original benign status. The theory of 
      clonal evolution is widely believed to explain malignant progression in 
      meningioma; however, the data used to explain stepwise progression have typically 
      been derived from the cytogenetic analysis of different types of tumors of 
      different grades and in different patients. In this study, the authors examined 
      the data obtained in a group of patients with meningiomas that showed clear 
      histopathological progression toward a higher grade of malignancy and then 
      analyzed the underlying cytogenetic findings. METHODS: Among 175 patients with 
      recurrent meningiomas, 11 tumors showed a histopathological progression toward a 
      higher grade that was associated with an aggressive clinical course. Six tumors 
      progressed to malignancy and five to the atypical category over a period 
      averaging 112 months. Tests for MIB-1 and p53 and cytogenetic studies with the 
      fluorescence in situ hybridization (FISH) method were performed in successive 
      specimens obtained in four patients. The MIB-1 value increased in subsequent 
      samples of tumors. Cytogenetic analysis with FISH showed deletions of 22, 1p, and 
      14q. In all but one case, these aberrations were also present in the previous 
      specimen despite its lower hispathological grade. CONCLUSIONS: The authors 
      documented the progression of meningiomas from benign to a higher histological 
      grade. These tumors were associated with a complex karyotype that was present ab 
      initio in a histologically lower-grade tumor, contradicting the stepwise clonal 
      evolution model. Although it was limited to the tested probes, the FISH method 
      appears to be more accurate than the standard cytogenetic one in detecting these 
      alterations. Tumors that present with complex genetic alterations, even those 
      with a benign histological grade, are potentially aggressive and require closer 
      follow up.
FAU - Al-Mefty, Ossama
AU  - Al-Mefty O
AD  - Department of Neurosurgery, University of Arkansas for Medical Sciences, Little 
      Rock, Arkansas, USA aekeeland@uams.edu
FAU - Kadri, Paulo A S
AU  - Kadri PA
FAU - Pravdenkova, Svetlana
AU  - Pravdenkova S
FAU - Sawyer, Jeffrey R
AU  - Sawyer JR
FAU - Stangeby, Colin
AU  - Stangeby C
FAU - Husain, Muhammad
AU  - Husain M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurosurg
JT  - Journal of neurosurgery
JID - 0253357
RN  - 0 (Ki-67 Antigen)
RN  - 0 (Tumor Suppressor Protein p53)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Chromosomes, Human, Pair 1/genetics
MH  - Chromosomes, Human, Pair 14/genetics
MH  - Chromosomes, Human, Pair 22/genetics
MH  - Cytogenetics/methods
MH  - Disease Progression
MH  - Documentation/methods
MH  - Female
MH  - Gene Deletion
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/methods
MH  - Ki-67 Antigen/*genetics
MH  - Male
MH  - Meningeal Neoplasms/*genetics/*pathology/surgery
MH  - Meningioma/*genetics/*pathology/surgery
MH  - Middle Aged
MH  - Neoplasm Recurrence, Local
MH  - Neurosurgical Procedures/instrumentation
MH  - Tumor Suppressor Protein p53/*genetics
EDAT- 2004/08/18 05:00
MHDA- 2004/09/03 05:00
CRDT- 2004/08/18 05:00
PHST- 2004/08/18 05:00 [pubmed]
PHST- 2004/09/03 05:00 [medline]
PHST- 2004/08/18 05:00 [entrez]
AID - 10.3171/jns.2004.101.2.0210 [doi]
PST - ppublish
SO  - J Neurosurg. 2004 Aug;101(2):210-8. doi: 10.3171/jns.2004.101.2.0210.