PMID- 15310862
OWN - NLM
STAT- MEDLINE
DCOM- 20050222
LR  - 20131121
IS  - 1096-6080 (Print)
IS  - 1096-0929 (Linking)
VI  - 82
IP  - 1
DP  - 2004 Nov
TI  - Effects of in utero exposure to 4-hydroxy-2,3,3',4',5-pentachlorobiphenyl 
      (4-OH-CB107) on developmental landmarks, steroid hormone levels, and female 
      estrous cyclicity in rats.
PG  - 259-67
AB  - Previous studies have revealed that one of the major metabolites of PCBs detected 
      in human blood, 4-OH-2,3,3',4',5-pentaCB (4-OH-CB107), accumulated in fetal 
      liver, brain, and plasma and reduced maternal and fetal thyroid hormone levels 
      after prenatal exposure to pregnant rats from gestational days (GD) 10-16. In the 
      present study, the effects of 4-OH-CB-107 on developmental landmarks, steroid 
      hormone levels, and estrous cyclicity of rat offspring after in utero exposure to 
      4-OH-CB107 was investigated. Pregnant rats were exposed to 0, 0.5, and 5.0 mg 
      4-OH-CB107 per kg bw from GD 10 to GD 16. Another group of rats was exposed to 
      Aroclor 1254 (25 mg/kg bw) to study the differences between effects caused by 
      parent PCB congeners and the 4-OH-CB107 alone. A significant, dose-dependent 
      prolongation of the estrous cycle was observed in 75% and 82% of female offspring 
      exposed to 0.5 and 5.0 mg 4-OH-PCB107, respectively, compared to 64% of Aroclor 
      1254 (25 mg/kg) exposed offspring. The diestrous stage of the estrous cycle was 
      prolonged, resembling a state of pseudopregnancy, which might reflect early signs 
      of reproductive senescence. Plasma estradiol concentrations in female rat 
      offspring were significantly increased (50%) in the proestrous stage after 
      exposure to 5 mg 4-OH-CB107 per kg bw. No effects on estradiol levels were 
      observed in Aroclor 1254 treated animals. These results indicate that in utero 
      exposure to 4-OH-CB107 leads to endocrine-disrupting effects, especially in 
      female offspring. The possible impact on neurobehavior following exposure to 
      4-OH-CB107 will be reported elsewhere.
FAU - Meerts, Ilonka A T M
AU  - Meerts IA
AD  - Toxicology Group, Wageningen University, Wageningen, The Netherlands. 
      ilonka.meerts@notox.nl
FAU - Hoving, Saske
AU  - Hoving S
FAU - van den Berg, Johannes H J
AU  - van den Berg JH
FAU - Weijers, Bert M
AU  - Weijers BM
FAU - Swarts, Hans J
AU  - Swarts HJ
FAU - van der Beek, Eline M
AU  - van der Beek EM
FAU - Bergman, Ake
AU  - Bergman A
FAU - Koeman, Jan H
AU  - Koeman JH
FAU - Brouwer, Abraham
AU  - Brouwer A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20040813
PL  - United States
TA  - Toxicol Sci
JT  - Toxicological sciences : an official journal of the Society of Toxicology
JID - 9805461
RN  - 0 (2,3,3',4',5-pentachloro-4-hydroxybiphenyl)
RN  - 0 (Aroclors)
RN  - 4TI98Z838E (Estradiol)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Administration, Oral
MH  - Animals
MH  - Aroclors/administration & dosage/toxicity
MH  - Dose-Response Relationship, Drug
MH  - Estradiol/*blood
MH  - Estrous Cycle/*drug effects/physiology
MH  - Female
MH  - Genitalia/drug effects/growth & development/pathology
MH  - Male
MH  - *Maternal Exposure
MH  - Polychlorinated Biphenyls/administration & dosage/*toxicity
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Rats
MH  - Rats, Wistar
MH  - Sexual Maturation/*drug effects
EDAT- 2004/08/18 05:00
MHDA- 2005/02/23 09:00
CRDT- 2004/08/18 05:00
PHST- 2004/08/18 05:00 [pubmed]
PHST- 2005/02/23 09:00 [medline]
PHST- 2004/08/18 05:00 [entrez]
AID - kfh251 [pii]
AID - 10.1093/toxsci/kfh251 [doi]
PST - ppublish
SO  - Toxicol Sci. 2004 Nov;82(1):259-67. doi: 10.1093/toxsci/kfh251. Epub 2004 Aug 13.