PMID- 15310946
OWN - NLM
STAT- MEDLINE
DCOM- 20050217
LR  - 20181130
IS  - 1386-0291 (Print)
IS  - 1386-0291 (Linking)
VI  - 31
IP  - 2
DP  - 2004
TI  - Hemorrheologic changes induced by aqueous extract of Ligaria cuneifolia: 
      treatment by two different administration routes.
PG  - 113-21
AB  - Ligaria cuneifolia (R. et P.) Tiegh. (Loranthaceae) (Argentine mistletoe) is 
      usually used in local folk medicine. This work focuses on the hemorrheologic 
      parameters in the treatment with an aqueous extract of Ligaria cuneifolia (Lc) by 
      two different administration routes: intraperitoneal (i.p.) and intravenous 
      (i.v.). Adult male Wistar rats were injected by via i.p. or by via i.v. with: 
      saline solution; 2.5 mg/100 g body weight of Lc and 5.5 mg/100 g body weight of 
      Lc. The relative viscosity of blood (eta r)(45/Hct) was measured showing that 
      Lc-treatment by via i.p. produced an increase of about 69% while Lc by via i.v. 
      enhanced the parameter about 47%. All of Lc-treated animals showed a significant 
      increase in the rigidity index (RI). The mean corpuscular hemoglobin 
      concentration (MCHC) exhibited an increase of about 15% in all the treated 
      groups. Lc-treatment by via i.p. produced a diminution of plasma cholesterol 
      level associated with RI augmentation which induced an increase of (eta 
      r)(45/Hct). By via i.v. Lc produces both RI and (eta r)(45/Hct) augmentation by 
      increasing MCHC but without modifying plasma cholesterol level, indicating a 
      direct Lc-action on the internal viscosity of the erythrocyte.
FAU - Dominighini, Alicia
AU  - Dominighini A
AD  - Cat. Biofisica, Facultad de Ciencias Medicas, Universidad Nacional de Rosario, 
      Argentina.
FAU - Ferrero, Mariana
AU  - Ferrero M
FAU - Mengarelli, Guillermo
AU  - Mengarelli G
FAU - Ronco, Maria Teresa
AU  - Ronco MT
FAU - de Lujan Alvarez, Maria
AU  - de Lujan Alvarez M
FAU - Wagner, Marcelo
AU  - Wagner M
FAU - Gurni, Alberto
AU  - Gurni A
FAU - Carnovale, Cristina
AU  - Carnovale C
FAU - Luquita, Alejandra
AU  - Luquita A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Clin Hemorheol Microcirc
JT  - Clinical hemorheology and microcirculation
JID - 9709206
RN  - 0 (Bile Acids and Salts)
RN  - 0 (Cholagogues and Choleretics)
RN  - 0 (Plant Extracts)
RN  - 059QF0KO0R (Water)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Animals
MH  - Argentina
MH  - Bile/metabolism
MH  - Bile Acids and Salts/metabolism
MH  - Blood Viscosity/drug effects
MH  - Cholagogues and Choleretics/pharmacology
MH  - Cholesterol/blood
MH  - Drug Evaluation, Preclinical
MH  - Erythrocyte Indices/drug effects
MH  - Erythrocytes/drug effects
MH  - Hemorheology/*drug effects
MH  - Injections, Intraperitoneal
MH  - Injections, Intravenous
MH  - Liver/drug effects
MH  - Loranthaceae/*chemistry
MH  - Male
MH  - Medicine, Traditional
MH  - Plant Extracts/administration & dosage/*pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Water
EDAT- 2004/08/18 05:00
MHDA- 2005/02/18 09:00
CRDT- 2004/08/18 05:00
PHST- 2004/08/18 05:00 [pubmed]
PHST- 2005/02/18 09:00 [medline]
PHST- 2004/08/18 05:00 [entrez]
PST - ppublish
SO  - Clin Hemorheol Microcirc. 2004;31(2):113-21.