PMID- 15311504
OWN - NLM
STAT- MEDLINE
DCOM- 20050812
LR  - 20140625
VI  - 18
IP  - 5
DP  - 2004 May
TI  - [Expression of inducible nitric oxide synthase mRNA in epithelial cell of nasal 
      mucosa is upregulated through Toll-like receptor-4].
PG  - 268-9
AB  - OBJECTIVE: To investigate the upregulation of inducible nitric oxide synthase 
      (iNOS) in epithelial cell of nasal mucosa through Toll-like receptor-4 (TLR-4). 
      METHOD: Specimens from 30 patients of chronic sinusitis and 21 healthy adults 
      were examined by in situ hybridization for TLR-4 and iNOS mRNA. RESULT: All 30 
      samples of chronic sinusitis showed a stronger expression of TLR-4 and iNOS than 
      in controls (P<0.01). iNOS upregulated in nasal epithelium correlated with TLR-4 
      (r=0.435, P<0.01). CONCLUSION: It suggested that TLR-4 may play a role in 
      enhancing local host defence and inflammation via upregulating the expression of 
      iNOS mRNA and the subsequent increased production of NO.
FAU - Wang, Chengshuo
AU  - Wang C
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, China-Japan Union 
      Hospital of Jilin University, Changchun, 130031, China.
FAU - Dong, Zhen
AU  - Dong Z
FAU - Guan, Guimei
AU  - Guan G
FAU - Yang, Zhanquan
AU  - Yang Z
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Ke Za Zhi
JT  - Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology
JID - 9426080
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (TLR4 protein, human)
RN  - 0 (Toll-Like Receptor 4)
RN  - 0 (Toll-Like Receptors)
RN  - EC 1.14.13.39 (NOS2 protein, human)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase Type II)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Chronic Disease
MH  - Female
MH  - Humans
MH  - Male
MH  - Membrane Glycoproteins/*biosynthesis/genetics
MH  - Middle Aged
MH  - Nasal Mucosa/*metabolism
MH  - Nitric Oxide Synthase/*biosynthesis/genetics
MH  - Nitric Oxide Synthase Type II
MH  - RNA, Messenger/biosynthesis/genetics
MH  - Receptors, Cell Surface/*biosynthesis/genetics
MH  - Sinusitis/metabolism
MH  - Toll-Like Receptor 4
MH  - Toll-Like Receptors
EDAT- 2004/08/18 05:00
MHDA- 2005/08/13 09:00
CRDT- 2004/08/18 05:00
PHST- 2004/08/18 05:00 [pubmed]
PHST- 2005/08/13 09:00 [medline]
PHST- 2004/08/18 05:00 [entrez]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2004 May;18(5):268-9.