PMID- 15312691
OWN - NLM
STAT- MEDLINE
DCOM- 20041018
LR  - 20151119
IS  - 0304-3835 (Print)
IS  - 0304-3835 (Linking)
VI  - 213
IP  - 1
DP  - 2004 Sep 15
TI  - Coexpression of hepatocyte growth factor/scatter factor (HGF/SF) and its receptor 
      cMET predict recurrence of meningiomas.
PG  - 117-24
AB  - Hepatocyte growth factor/scatter factor (HGF/SF) and its receptor, the cMET 
      tyrosine kinase participate in cancer invasion, angiogenesis and metastasis in a 
      wide variety of neoplastic cells. Meningioma is a bening tumour, however, it has 
      a high rate of recurrence after surgery; the most important factor to predict 
      relapse is the extent of surgical resection, several other potentially predictive 
      factors have been studied with poor results. We examined by immunohistochemistry 
      the expression of HGF/SF and its cMET receptor in a group of patients with benign 
      meningioma with or without recurrence (n = 17 and n = 25, respectively), after a 
      minimal follow-up of least 6 years. Expression and coexpression of HGF/SF and 
      cMET were compared with cell proliferation index, vascular density and clinical 
      outcome. Coexpression of HGF/SF and cMET in meningiomas had a significant 
      association with cell proliferation index and with recurrence (P < 0.037). 
      Determination of HGF and cMET coexpression in meningiomas could be used as a 
      predictor of recurrence.
FAU - Martinez-Rumayor, Abelardo
AU  - Martinez-Rumayor A
AD  - Neuroimmunology Unit, National Institute of Neurology and Neurosurgery of Mexico, 
      Insurgentes Sur 3877, Col. La Fama, 14269 Mexico City, Mexico.
FAU - Arrieta, Oscar
AU  - Arrieta O
FAU - Guevara, Patricia
AU  - Guevara P
FAU - Escobar, Elizabeth
AU  - Escobar E
FAU - Rembao, Daniel
AU  - Rembao D
FAU - Salina, Citlaltepetl
AU  - Salina C
FAU - Sotelo, Julio
AU  - Sotelo J
LA  - eng
PT  - Journal Article
PL  - Ireland
TA  - Cancer Lett
JT  - Cancer letters
JID - 7600053
RN  - 0 (Biomarkers, Tumor)
RN  - 67256-21-7 (Hepatocyte Growth Factor)
RN  - EC 2.7.10.1 (Proto-Oncogene Proteins c-met)
SB  - IM
MH  - Adult
MH  - Biomarkers, Tumor/*analysis
MH  - Female
MH  - Follow-Up Studies
MH  - *Gene Expression Profiling
MH  - Hepatocyte Growth Factor/*biosynthesis
MH  - Humans
MH  - Immunohistochemistry
MH  - Male
MH  - Meningeal Neoplasms/*genetics/*pathology
MH  - Meningioma/*genetics/*pathology
MH  - Middle Aged
MH  - *Neoplasm Recurrence, Local
MH  - Prognosis
MH  - Proto-Oncogene Proteins c-met/*biosynthesis
MH  - Treatment Outcome
EDAT- 2004/08/18 05:00
MHDA- 2004/10/19 09:00
CRDT- 2004/08/18 05:00
PHST- 2003/10/07 00:00 [received]
PHST- 2004/02/18 00:00 [revised]
PHST- 2004/04/15 00:00 [accepted]
PHST- 2004/08/18 05:00 [pubmed]
PHST- 2004/10/19 09:00 [medline]
PHST- 2004/08/18 05:00 [entrez]
AID - S0304-3835(04)00316-7 [pii]
AID - 10.1016/j.canlet.2004.04.026 [doi]
PST - ppublish
SO  - Cancer Lett. 2004 Sep 15;213(1):117-24. doi: 10.1016/j.canlet.2004.04.026.