PMID- 15313152
OWN - NLM
STAT- MEDLINE
DCOM- 20041223
LR  - 20131121
IS  - 0009-8981 (Print)
IS  - 0009-8981 (Linking)
VI  - 347
IP  - 1-2
DP  - 2004 Sep
TI  - Fenofibrate reduces tumor necrosis factor-alpha serum concentration and adipocyte 
      secretion of hypercholesterolemic rabbits.
PG  - 145-50
AB  - BACKGROUND: Tumor necrosis factor-alpha (TNF-alpha) is produced by cells of the 
      macrophage-monocyte lineage and by adipocytes. It may provide the link between 
      inflammation and atherosclerosis. The aim of this study was to evaluate the 
      effect of fenofibrate on serum TNF-alpha concentration and TNF-alpha secretion by 
      adipocytes from hypercholesterolemic rabbits. METHODS: Ten male New Zealand white 
      rabbits were fed with high-cholesterol diet for 8 weeks, and were randomly 
      divided into two groups: (1) high cholesterol group: maintained cholesterol diet 
      for 4 weeks; and (2) fenofibrate treated group: the same cholesterol diet 
      supplemented with fenofibrate (30 mg/kg/day) for 4 weeks. Control group was fed 
      with normal diet for 12 weeks. Subcutaneous adipose was collected for adipocytes 
      culture. TNF-alpha concentrations in serum and adipocytes culture supernatant 
      were measured by ELISA. RESULTS: Rabbits fed with high-cholesterol diet showed 
      higher serum levels of total cholesterol, low density lipoprotein cholesterol 
      than those fed with normal diet (P<0.001). Fenofibrate treatment did not change 
      serum lipid levels during the feeding period, but decreased high cholesterol 
      diet-induced increases in body weight by 19% and serum TNF-alpha concentration by 
      44.7% in fenofibrate treated group compared with high cholesterol group (P<0.05). 
      The decreased levels of TNF-alpha correlated with the weight loss (r=0.35, 
      P<0.05). Fenofibrate (10 to 100 micromol/l) significantly reduced release of 
      TNF-alpha in adipocytes (P<0.05). Meanwhile serum TNF-alpha concentration were 
      significantly correlated with TNF-alpha secretion in adipocytes (r=0.51, P<0.05). 
      CONCLUSIONS: Our study indicated that fenofibrate reduced tumor necrosis 
      factor-alpha serum concentration and adipocyte secretion of hypercholesterolemic 
      rabbits. This effect of fenofibrate might contribute to its benefits on the 
      prevention and treatment of atherosclerosis.
FAU - Zhao, Shui-Ping
AU  - Zhao SP
AD  - Department of Cardiology, The Second Xiangya Hospital of Central South 
      University, middle Ren-Min road No. 86, Changsha, Hunan 410011, PR China.
FAU - Wu, Jie
AU  - Wu J
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Clin Chim Acta
JT  - Clinica chimica acta; international journal of clinical chemistry
JID - 1302422
RN  - 0 (Hypolipidemic Agents)
RN  - 0 (Lipids)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - U202363UOS (Fenofibrate)
SB  - IM
MH  - Adipocytes/drug effects/*metabolism
MH  - Animals
MH  - Body Weight
MH  - Cells, Cultured
MH  - Depression, Chemical
MH  - Dose-Response Relationship, Drug
MH  - Fenofibrate/*pharmacology
MH  - Hypercholesterolemia/*metabolism
MH  - Hypolipidemic Agents/*pharmacology
MH  - Lipids/blood
MH  - Male
MH  - Rabbits
MH  - Tumor Necrosis Factor-alpha/*metabolism
EDAT- 2004/08/18 05:00
MHDA- 2004/12/24 09:00
CRDT- 2004/08/18 05:00
PHST- 2004/02/29 00:00 [received]
PHST- 2004/04/13 00:00 [revised]
PHST- 2004/04/14 00:00 [accepted]
PHST- 2004/08/18 05:00 [pubmed]
PHST- 2004/12/24 09:00 [medline]
PHST- 2004/08/18 05:00 [entrez]
AID - S0009898104001986 [pii]
AID - 10.1016/j.cccn.2004.04.001 [doi]
PST - ppublish
SO  - Clin Chim Acta. 2004 Sep;347(1-2):145-50. doi: 10.1016/j.cccn.2004.04.001.