PMID- 15313390
OWN - NLM
STAT- MEDLINE
DCOM- 20040927
LR  - 20161124
IS  - 0006-2952 (Print)
IS  - 0006-2952 (Linking)
VI  - 68
IP  - 6
DP  - 2004 Sep 15
TI  - HIF-1: master and commander of the hypoxic world. A pharmacological approach to 
      its regulation by siRNAs.
PG  - 971-80
AB  - The hypoxia-inducible factor-1 (HIF-1) is primarily involved in the sensing and 
      adapting of cells to changes in the O2 level, which is essential for their 
      viability. It is important that this critical transcription factor be tightly 
      regulated in order for cells to respond to a wide range of O2 concentrations. 
      HIF-1 regulation by post-translational modification is the central theme of the 
      scenario of O2 homeostasis. The alpha subunit of HIF-1 is the principal actor 
      while the supporting actors (PHDs, FIH-1, ARD1, CITED2, p300...) all contribute 
      to the complexity of the grand finale. It is well established that HIF-1 
      expression and activation correlates with tumor progression and resistance to 
      cancer treatments. We will introduce the different actors involved in HIF-1 
      regulation, and their mechanisms of action via invalidation by siRNAs and discuss 
      therapies targeting HIF-1, to selectively kill tumor cells that adapt to low O2 
      concentrations.
FAU - Mazure, Nathalie M
AU  - Mazure NM
AD  - Institute of Signaling, Developmental Biology and Cancer Research, CNRS-UMR 6543, 
      Centre Antoine Lacassagne, 33 Avenue de Valombrose, 06189 Nice, France.
FAU - Brahimi-Horn, M Christiane
AU  - Brahimi-Horn MC
FAU - Berta, Melanie A
AU  - Berta MA
FAU - Benizri, Emmanuel
AU  - Benizri E
FAU - Bilton, Rebecca L
AU  - Bilton RL
FAU - Dayan, Frederic
AU  - Dayan F
FAU - Ginouves, Amandine
AU  - Ginouves A
FAU - Berra, Edurne
AU  - Berra E
FAU - Pouyssegur, Jacques
AU  - Pouyssegur J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Biochem Pharmacol
JT  - Biochemical pharmacology
JID - 0101032
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (HIF1A protein, human)
RN  - 0 (Hypoxia-Inducible Factor 1)
RN  - 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
RN  - 0 (Nuclear Proteins)
RN  - 0 (RNA, Small Interfering)
RN  - 0 (TRIM23 protein, human)
RN  - 0 (Transcription Factors)
RN  - 0 (Tumor Suppressor Proteins)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - EC 1.14.11.2 (Procollagen-Proline Dioxygenase)
RN  - EC 2.3.2.27 (Ubiquitin-Protein Ligases)
RN  - EC 2.3.2.27 (Von Hippel-Lindau Tumor Suppressor Protein)
RN  - EC 3.6.1.- (GTP-Binding Proteins)
RN  - EC 6.3.2.- (VHL protein, human)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Animals
MH  - Cell Hypoxia
MH  - DNA-Binding Proteins/antagonists & inhibitors/*metabolism
MH  - GTP-Binding Proteins/metabolism
MH  - Humans
MH  - Hypoxia-Inducible Factor 1
MH  - Hypoxia-Inducible Factor 1, alpha Subunit
MH  - Nitric Oxide/metabolism
MH  - Nuclear Proteins/antagonists & inhibitors/*metabolism
MH  - Oxygen/*metabolism
MH  - Procollagen-Proline Dioxygenase/metabolism
MH  - RNA, Small Interfering/*pharmacology
MH  - Signal Transduction
MH  - *Transcription Factors
MH  - Tumor Suppressor Proteins/metabolism
MH  - Ubiquitin-Protein Ligases/metabolism
MH  - Von Hippel-Lindau Tumor Suppressor Protein
RF  - 67
EDAT- 2004/08/18 05:00
MHDA- 2004/09/28 05:00
CRDT- 2004/08/18 05:00
PHST- 2004/03/23 00:00 [received]
PHST- 2004/04/21 00:00 [accepted]
PHST- 2004/08/18 05:00 [pubmed]
PHST- 2004/09/28 05:00 [medline]
PHST- 2004/08/18 05:00 [entrez]
AID - S0006295204003508 [pii]
AID - 10.1016/j.bcp.2004.04.022 [doi]
PST - ppublish
SO  - Biochem Pharmacol. 2004 Sep 15;68(6):971-80. doi: 10.1016/j.bcp.2004.04.022.