PMID- 15313818
OWN - NLM
STAT- MEDLINE
DCOM- 20040910
LR  - 20080317
IS  - 0003-987X (Print)
IS  - 0003-987X (Linking)
VI  - 140
IP  - 8
DP  - 2004 Aug
TI  - Immune reconstitution inflammatory syndrome associated with HIV and leprosy.
PG  - 997-1000
AB  - BACKGROUND: Immune reconstitution inflammatory syndrome (IRIS) is an unusual 
      inflammatory reaction to an opportunistic infection that occurs in human 
      immunodeficiency virus (HIV)-positive patients with profound immunosuppression 
      during the reconstitution of the immune system in the initial months of highly 
      active antiretroviral treatment. OBSERVATIONS: We describe 3 cases of leprosy 
      occurring in patients treated with a combination of 3 antiretroviral drugs who 
      fulfilled the criteria for IRIS. A reactional state occurred in all 3 cases. Two 
      of the 3 patients presented an unusual ulcerous progression of the lesions not 
      generally observed in cases of leprosy. The outcome was favorable in all 3 cases. 
      The frequency of IRIS associated with leprosy in French Guiana and Martinique is 
      estimated at 3 cases per 1000 HIV-positive patients receiving highly active 
      antiretroviral treatment. CONCLUSION: Leprosy should be recognized as an 
      IRIS-associated infection with possibility of atypical presentation.
FAU - Couppie, Pierre
AU  - Couppie P
AD  - Institut Guyanais de Dermatologie Tropicale, Service de Dermatologie, Centre 
      d'Information et de Soins de l'Immunodeficience Humaine de Guyane, Centre 
      Hospitalier de Cayenne, French Guiana. couppie.pierre@voila.fr
FAU - Abel, Sylvie
AU  - Abel S
FAU - Voinchet, Helene
AU  - Voinchet H
FAU - Roussel, Morgane
AU  - Roussel M
FAU - Helenon, Raymond
AU  - Helenon R
FAU - Huerre, Michel
AU  - Huerre M
FAU - Sainte-Marie, Dominique
AU  - Sainte-Marie D
FAU - Cabie, Andre
AU  - Cabie A
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Arch Dermatol
JT  - Archives of dermatology
JID - 0372433
RN  - 0 (Anti-HIV Agents)
RN  - 0 (Leprostatic Agents)
SB  - IM
MH  - AIDS-Related Opportunistic Infections/diagnosis/drug therapy/pathology
MH  - Anti-HIV Agents/administration & dosage/adverse effects
MH  - Autoimmune Diseases/chemically induced/*diagnosis/drug therapy/pathology
MH  - Diagnosis, Differential
MH  - Female
MH  - HIV Infections/*diagnosis/drug therapy
MH  - Humans
MH  - Leprostatic Agents/administration & dosage
MH  - Leprosy/*diagnosis/drug therapy/pathology
MH  - Male
MH  - Middle Aged
EDAT- 2004/08/18 05:00
MHDA- 2004/09/11 05:00
CRDT- 2004/08/18 05:00
PHST- 2004/08/18 05:00 [pubmed]
PHST- 2004/09/11 05:00 [medline]
PHST- 2004/08/18 05:00 [entrez]
AID - 140/8/997 [pii]
AID - 10.1001/archderm.140.8.997 [doi]
PST - ppublish
SO  - Arch Dermatol. 2004 Aug;140(8):997-1000. doi: 10.1001/archderm.140.8.997.