PMID- 15317322
OWN - NLM
STAT- MEDLINE
DCOM- 20050329
LR  - 20161020
IS  - 1088-5412 (Print)
IS  - 1088-5412 (Linking)
VI  - 25
IP  - 3
DP  - 2004 May-Jun
TI  - Age effects on objective measures of atopy in adult asthma and rhinitis.
PG  - 175-9
AB  - A cross-sectional survey of 132 adult men referred to the outpatient allergy 
      clinic at the West Los Angeles Veterans Affairs Medical Center was performed to 
      assess age effects on allergic disease in the elderly. Total serum immunoglobulin 
      E (IgE), immediate hypersensitivity skin testing, and serum eosinophil count were 
      measured in all subjects. Subjects were stratified by age into one of five groups 
      for comparison. In asthma, prevalence of allergy skin test reactivity and mean 
      total serum IgE levels did not decline with advancing age, suggesting that 
      IgE-dependent mechanisms continue to be significant in elderly patients with 
      asthma. In subjects with rhinitis, prevalence of allergy skin test reactivity and 
      mean total serum IgE did decline among elderly subjects relative to younger 
      subjects. However, the prevalence of allergic rhinitis did not decline in the 
      elderly. This suggests that although allergic rhinitis is common in elderly 
      patients, nonallergic causes of rhinitis may become more prevalent with advancing 
      age.
FAU - Crawford, William W
AU  - Crawford WW
AD  - Division of Allergy and Immunology, Department of Medicine, Veterans Affairs 
      Greater Los Angeles Health Care System, The David Geffen School of Medicine, 
      University of California, Los Angeles, California 90073, USA.
FAU - Gowda, Vinay C
AU  - Gowda VC
FAU - Klaustermeyer, William B
AU  - Klaustermeyer WB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Allergy Asthma Proc
JT  - Allergy and asthma proceedings
JID - 9603640
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - *Age Factors
MH  - Aged
MH  - Asthma/blood/*diagnosis/etiology
MH  - Cross-Sectional Studies
MH  - Eosinophils
MH  - Humans
MH  - Hypersensitivity, Immediate/blood/complications/*diagnosis
MH  - Immunoglobulin E/*blood
MH  - Leukocyte Count
MH  - Male
MH  - Middle Aged
MH  - Rhinitis/blood/*diagnosis/etiology
MH  - Skin Tests
EDAT- 2004/08/20 05:00
MHDA- 2005/03/30 09:00
CRDT- 2004/08/20 05:00
PHST- 2004/08/20 05:00 [pubmed]
PHST- 2005/03/30 09:00 [medline]
PHST- 2004/08/20 05:00 [entrez]
PST - ppublish
SO  - Allergy Asthma Proc. 2004 May-Jun;25(3):175-9.