PMID- 15319266
OWN - NLM
STAT- MEDLINE
DCOM- 20050324
LR  - 20131121
IS  - 1524-4636 (Electronic)
IS  - 1079-5642 (Linking)
VI  - 24
IP  - 10
DP  - 2004 Oct
TI  - High-density lipoproteins retard the progression of atherosclerosis and favorably 
      remodel lesions without suppressing indices of inflammation or oxidation.
PG  - 1904-9
AB  - OBJECTIVE: Protective properties of high-density lipoproteins (HDL) may include 
      reverse cholesterol transport and suppression of oxidation and inflammation. 
      These were investigated in vivo, as were the effects of HDL on the 
      characteristics of atherosclerotic lesions. METHODS AND RESULTS: Male 
      apolipoprotein E knockout (apoE-/-) and apoE-/- mice expressing human 
      apolipoprotein AI (hAI/apoE-/-) were studied up to 20 weeks after commencing a 
      high-fat diet. Plasma HDL cholesterol was twice as high in hAI/apoE-/- mice. Over 
      time, aortic root lesion area remained less in hAI/apoE-/- mice, although plaques 
      became complex. In advanced lesions, plaque lipid was higher in apoE-/- mice, 
      whereas plaque collagen and alpha actin were increased in hAI/apoE-/- mice. In 
      nonlesional aorta, mRNA abundance for pro-inflammatory proteins (vascular cell 
      adhesion molecule [VCAM]-1, intercellular adhesion molecule-1 [ICAM-1], monocyte 
      chemoattractant protein-1 [MCP-1]) increased between 4 and 16 weeks in apoE-/- 
      (but not wild-type) mice, and were not reduced by elevated HDL. Autoantibodies to 
      malondialdehyde low-density lipoprotein (LDL) increased progressively in apoE-/- 
      mice, with similar results in hAI/apoE-/- mice. CONCLUSIONS: HDL retarded plaque 
      size progression despite greatly elevated plasma cholesterol. This effect was 
      over a wide range of lesion severity. Expression of hAI reduced plaque lipid and 
      increased the proportion of plaque occupied by collagen and smooth muscle cells, 
      but did not affect indicators of inflammation or LDL oxidation.
FAU - Choudhury, Robin P
AU  - Choudhury RP
AD  - Department of Medicine, Marc and Ruti Bell Program in Vascular Biology in the 
      Leon H. Charney Division of Cardiology, and Cell Biology, New York University 
      School of Medicine, New York, NY 10016, USA.
FAU - Rong, James X
AU  - Rong JX
FAU - Trogan, Eugene
AU  - Trogan E
FAU - Elmalem, Valerie I
AU  - Elmalem VI
FAU - Dansky, Hayes M
AU  - Dansky HM
FAU - Breslow, Jan L
AU  - Breslow JL
FAU - Witztum, Joseph L
AU  - Witztum JL
FAU - Fallon, John T
AU  - Fallon JT
FAU - Fisher, Edward A
AU  - Fisher EA
LA  - eng
GR  - HL-61814/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20040819
PL  - United States
TA  - Arterioscler Thromb Vasc Biol
JT  - Arteriosclerosis, thrombosis, and vascular biology
JID - 9505803
RN  - 0 (Apolipoprotein A-I)
RN  - 0 (Apolipoproteins E)
RN  - 0 (Autoantibodies)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Lipoproteins, HDL)
RN  - 0 (Lipoproteins, LDL)
RN  - 0 (RNA, Messenger)
RN  - 0 (Vascular Cell Adhesion Molecule-1)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Animals
MH  - Apolipoprotein A-I/biosynthesis/blood
MH  - Apolipoproteins E
MH  - Arteriosclerosis/*prevention & control
MH  - Autoantibodies
MH  - Chemokine CCL2/metabolism
MH  - Cholesterol/blood
MH  - Humans
MH  - Inflammation/pathology
MH  - Intercellular Adhesion Molecule-1/metabolism
MH  - Lipoproteins, HDL/*physiology
MH  - Lipoproteins, LDL/immunology
MH  - Male
MH  - Malondialdehyde/immunology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Neovascularization, Physiologic/*physiology
MH  - Oxidation-Reduction
MH  - RNA, Messenger/metabolism
MH  - Vascular Cell Adhesion Molecule-1/metabolism
EDAT- 2004/08/21 05:00
MHDA- 2005/03/25 09:00
CRDT- 2004/08/21 05:00
PHST- 2004/08/21 05:00 [pubmed]
PHST- 2005/03/25 09:00 [medline]
PHST- 2004/08/21 05:00 [entrez]
AID - 01.ATV.0000142808.34602.25 [pii]
AID - 10.1161/01.ATV.0000142808.34602.25 [doi]
PST - ppublish
SO  - Arterioscler Thromb Vasc Biol. 2004 Oct;24(10):1904-9. doi: 
      10.1161/01.ATV.0000142808.34602.25. Epub 2004 Aug 19.