PMID- 15319362
OWN - NLM
STAT- MEDLINE
DCOM- 20050314
LR  - 20120215
IS  - 1530-6860 (Electronic)
IS  - 0892-6638 (Linking)
VI  - 18
IP  - 13
DP  - 2004 Oct
TI  - Effect of caloric restriction on life span of the housefly, Musca domestica.
PG  - 1591-3
AB  - Caloric restriction (CR) has been found to extend the life spans of a wide 
      variety of species, transcending phylogenetic boundaries. The objective of this 
      study was to test the generality of this phenomenon, using the male housefly as 
      an insect model in which food intake can be quantified precisely. Sucrose was 
      found to promote a longer life span than diets additionally containing proteins 
      and lipids. Flies were fed sucrose or a more complex diet ad libitum (AL), or in 
      amounts ranging from 50% to 100% of the average amount consumed by young flies. 
      CR shortened rather than prolonged the life span of houseflies, particularly 
      flies fed sucrose only. The rate of oxygen consumption was not affected by 
      caloric restriction or by the exclusion of proteins and lipids from the diet, and 
      the reproductive activity of male flies remained unchanged by sucrose feeding. 
      Thus, it is unlikely that the life-shortening effects of CR can be explained 
      either in terms of an adaptive response in metabolic rate or use of a suboptimal 
      food source. Results of this study contradict the widely held view that CR has a 
      life-extending effect in all species.
FAU - Cooper, T Michael
AU  - Cooper TM
AD  - Department of Biological Sciences, Southern Methodist University,Dallas, Texas 
      75275, USA.
FAU - Mockett, Robin J
AU  - Mockett RJ
FAU - Sohal, Barbara H
AU  - Sohal BH
FAU - Sohal, Rajindar S
AU  - Sohal RS
FAU - Orr, William C
AU  - Orr WC
LA  - eng
GR  - R01 AG7657/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20040819
PL  - United States
TA  - FASEB J
JT  - FASEB journal : official publication of the Federation of American Societies for 
      Experimental Biology
JID - 8804484
SB  - IM
MH  - Aging/drug effects/physiology
MH  - Animals
MH  - *Caloric Restriction
MH  - Diet
MH  - Fertility/drug effects/physiology
MH  - Houseflies/*drug effects/*physiology
MH  - Longevity/*drug effects/physiology
MH  - Male
MH  - Oxygen Consumption/drug effects/physiology
MH  - Starvation/chemically induced/physiopathology
MH  - Survival Analysis
EDAT- 2004/08/21 05:00
MHDA- 2005/03/15 09:00
CRDT- 2004/08/21 05:00
PHST- 2004/08/21 05:00 [pubmed]
PHST- 2005/03/15 09:00 [medline]
PHST- 2004/08/21 05:00 [entrez]
AID - 03-1464fje [pii]
AID - 10.1096/fj.03-1464fje [doi]
PST - ppublish
SO  - FASEB J. 2004 Oct;18(13):1591-3. doi: 10.1096/fj.03-1464fje. Epub 2004 Aug 19.