PMID- 15319381
OWN - NLM
STAT- MEDLINE
DCOM- 20050323
LR  - 20221207
IS  - 0268-1161 (Print)
IS  - 0268-1161 (Linking)
VI  - 19
IP  - 11
DP  - 2004 Nov
TI  - The tumor necrosis factor-alpha promoter -1031C polymorphism is associated with 
      decreased risk of endometriosis in a Japanese population.
PG  - 2509-14
AB  - BACKGROUND: Tumor necrosis factor-alpha (TNF-alpha) is a multifunctional 
      proinflammatory cytokine, associated with various inflammatory and autoimmune 
      diseases. Elevated TNF-alpha levels in peritoneal fluid have been reported in 
      women with endometriosis, suggesting that TNF-alpha may be involved in the 
      development of endometriosis. In this study, we investigated the possible 
      association between endometriosis and the TNF-alpha gene promoter polymorphisms 
      -238G/A, -308G/A, -857C/T, -863C/A and -1031T/C in a Japanese population. 
      METHODS: We compared the distribution of the -238G/A, -308G/A, -857C/T, -863C/A 
      and -1031T/C polymorphisms in the promoter region of TNF-alpha in 130 
      endometriosis cases and 185 controls using PCR-RFLP analysis. RESULTS: The allele 
      frequencies of -238A, -308A, -857T, -863A and -1031C in controls were 2.0%, 1.3%, 
      19.4%, 17.0% and 18.6%, and in the cases 1.1%, 0.3%, 19.6%, 18.6% and 13.6%, 
      respectively. No significant differences in frequencies were found between the 
      crude endometriosis cases and controls. However, when the endometriosis group was 
      divided into a subgroup of women with stage IV disease only, the frequency of the 
      -1031C allele was significantly lower in this subgroup than controls. 
      CONCLUSIONS: The variability of the -1031T/C polymorphism of the TNF-alpha gene 
      may be associated with susceptibility to (AUTHOR: as meant?) endometriosis.
FAU - Asghar, Tasneem
AU  - Asghar T
AD  - Department of Obstetrics and Gynecology, Kobe University Graduate School of 
      Medicine, 7-5-1 Kusunoki-Cho, chuo-ku, Kobe, 650-0017, Japan.
FAU - Yoshida, Shigeki
AU  - Yoshida S
FAU - Kennedy, Stephen
AU  - Kennedy S
FAU - Negoro, Kenichi
AU  - Negoro K
FAU - Zhuo, Wang
AU  - Zhuo W
FAU - Hamana, Shinya
AU  - Hamana S
FAU - Motoyama, Satoru
AU  - Motoyama S
FAU - Nakago, Satoshi
AU  - Nakago S
FAU - Barlow, David
AU  - Barlow D
FAU - Maruo, Takeshi
AU  - Maruo T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20040819
PL  - England
TA  - Hum Reprod
JT  - Human reproduction (Oxford, England)
JID - 8701199
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Asian People/*genetics
MH  - Case-Control Studies
MH  - Endometriosis/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Genetics, Population
MH  - Humans
MH  - Infant, Newborn
MH  - Japan
MH  - *Polymorphism, Genetic
MH  - Pregnancy
MH  - Promoter Regions, Genetic/*genetics
MH  - Tumor Necrosis Factor-alpha/*genetics
EDAT- 2004/08/21 05:00
MHDA- 2005/03/24 09:00
CRDT- 2004/08/21 05:00
PHST- 2004/08/21 05:00 [pubmed]
PHST- 2005/03/24 09:00 [medline]
PHST- 2004/08/21 05:00 [entrez]
AID - deh478 [pii]
AID - 10.1093/humrep/deh478 [doi]
PST - ppublish
SO  - Hum Reprod. 2004 Nov;19(11):2509-14. doi: 10.1093/humrep/deh478. Epub 2004 Aug 
      19.