PMID- 1532001
OWN - NLM
STAT- MEDLINE
DCOM- 19920415
LR  - 20061115
IS  - 0022-1767 (Print)
IS  - 0022-1767 (Linking)
VI  - 148
IP  - 7
DP  - 1992 Apr 1
TI  - Cytokine-induced production of monocyte chemoattractant protein-1 by cultured 
      human mesangial cells.
PG  - 2148-53
AB  - The infiltration of the glomerulus by monocyte-derived macrophages is an 
      important step in the pathogenesis of glomerular injury. The factors regulating 
      glomerular leukocyte traffic remain unknown. We postulated that the glomerular 
      mesangial cell (MC) may participate in the development of glomerular inflammation 
      through the production of the monocyte-specific chemotactic factor, monocyte 
      chemoattractant protein-1 (MCP-1). Using a cell culture system, we found that 
      human MC produced a basal level of monocyte chemotactic activity, which was 
      significantly increased by the inflammatory cytokines IL-1 beta and TNF-alpha. 
      This increase in bioactivity correlated with the increased expression of MCP-1 
      mRNA by cytokine-conditioned MC. The total chemotactic activity of MC-conditioned 
      supernatants was reduced by more than 80% after immunoadsorption with a specific 
      anti-MCP-1 antibody. Thus, MC could play a role in inflammatory glomerular 
      conditions through the production of MCP-1.
FAU - Rovin, B H
AU  - Rovin BH
AD  - Department of Medicine, Ohio State University, Columbus 43210.
FAU - Yoshiumura, T
AU  - Yoshiumura T
FAU - Tan, L
AU  - Tan L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Immunol
JT  - Journal of immunology (Baltimore, Md. : 1950)
JID - 2985117R
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemotactic Factors)
RN  - 0 (IL1RN protein, human)
RN  - 0 (Interleukin 1 Receptor Antagonist Protein)
RN  - 0 (Interleukin-1)
RN  - 0 (Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Sialoglycoproteins)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Cells, Cultured
MH  - Chemokine CCL2
MH  - Chemotactic Factors/*biosynthesis/genetics
MH  - Glomerular Mesangium/*metabolism
MH  - Glomerulonephritis/etiology
MH  - Humans
MH  - Interleukin 1 Receptor Antagonist Protein
MH  - Interleukin-1/*pharmacology
MH  - Macrophages/physiology
MH  - Proteins/pharmacology
MH  - RNA, Messenger/analysis
MH  - *Sialoglycoproteins
MH  - Tumor Necrosis Factor-alpha/*pharmacology
EDAT- 1992/04/01 00:00
MHDA- 1992/04/01 00:01
CRDT- 1992/04/01 00:00
PHST- 1992/04/01 00:00 [pubmed]
PHST- 1992/04/01 00:01 [medline]
PHST- 1992/04/01 00:00 [entrez]
PST - ppublish
SO  - J Immunol. 1992 Apr 1;148(7):2148-53.