PMID- 15322432
OWN - NLM
STAT- MEDLINE
DCOM- 20050201
LR  - 20191108
IS  - 1052-9551 (Print)
IS  - 1052-9551 (Linking)
VI  - 13
IP  - 3
DP  - 2004 Sep
TI  - Characterization of chromosomal rearrangements in hematological diseases using 
      spectral karyotyping.
PG  - 190-5
AB  - Since chromosomal changes are used both as independent prognostic factors and for 
      therapy design in hematological disorders, it is necessary to elucidate 
      chromosomal changes as accurately as possible. We used spectral karyotyping (SKY) 
      and fluorescence in situ hybridization (FISH) to further characterize chromosomal 
      abnormalities in 35 patients with hematological disorders. SKY confirmed 149 
      aberrations, refined 117, and detected 11 hidden changes. Eighteen abnormalities 
      were detected only by G-banding. Ten monosomies and two deletions described by 
      G-banding were shown to be involved in translocations or ring chromosomes. These 
      results demonstrate that SKY increases the accuracy of karyotype interpretation, 
      which is important for proper diagnosis and management of hematological 
      malignancies.
FAU - Tchinda, Joelle
AU  - Tchinda J
AD  - Institut fur Humangenetik, Universitatsklinikum Munster, Munster, Germany. 
      tchinda@uni-muenster.de
FAU - Neumann, Thomas E
AU  - Neumann TE
FAU - Volpert, Sarah
AU  - Volpert S
FAU - Berdel, Wolfgang E
AU  - Berdel WE
FAU - Buchner, Thomas
AU  - Buchner T
FAU - Horst, Jurgen
AU  - Horst J
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Diagn Mol Pathol
JT  - Diagnostic molecular pathology : the American journal of surgical pathology, part 
      B
JID - 9204924
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Child, Preschool
MH  - Female
MH  - Gene Rearrangement/*genetics
MH  - Hematologic Diseases/*genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Infant
MH  - Male
MH  - Middle Aged
MH  - *Spectral Karyotyping
EDAT- 2004/08/24 05:00
MHDA- 2005/02/03 09:00
CRDT- 2004/08/24 05:00
PHST- 2004/08/24 05:00 [pubmed]
PHST- 2005/02/03 09:00 [medline]
PHST- 2004/08/24 05:00 [entrez]
AID - 00019606-200409000-00010 [pii]
AID - 10.1097/01.pas.0000124338.49401.ef [doi]
PST - ppublish
SO  - Diagn Mol Pathol. 2004 Sep;13(3):190-5. doi: 10.1097/01.pas.0000124338.49401.ef.