PMID- 15322540
OWN - NLM
STAT- MEDLINE
DCOM- 20040930
LR  - 20210102
IS  - 1529-2908 (Print)
IS  - 1529-2908 (Linking)
VI  - 5
IP  - 9
DP  - 2004 Sep
TI  - Upregulation of the CLIP self peptide on mature dendritic cells antagonizes T 
      helper type 1 polarization.
PG  - 909-18
AB  - Dendritic cells (DCs) initiate and regulate immunity against foreign and self 
      antigens. Here we identified more than 200 individual major histocompatibility 
      complex class II-associated peptides on human DCs and found that mature DCs 
      selectively upregulated the self peptide CLIP. CLIP cosegregated together with 
      foreign antigenic peptides in tetraspan microdomains on the surface and localized 
      to DC-T cell synapses. The increased representation of CLIP-major 
      histocompatibility complex class II complexes favored polarization of autologous 
      naive T cells toward the nonpolarized and T helper type 2 (T(H)2) phenotype. 
      There was also a considerably higher T(H)2/T(H)1 ratio in H2-DM-deficient mice, 
      which have a CLIP(hi) phenotype, in contrast to wild-type, CLIP(lo) mice. Thus, 
      the self peptide CLIP on DCs qualifies as an endogenous regulator in priming of T 
      helper cells by antagonizing the polarization toward the T(H)1 phenotype.
FAU - Rohn, Till A
AU  - Rohn TA
AD  - Basel Institute for Immunology, Basel, Switzerland.
FAU - Boes, Marianne
AU  - Boes M
FAU - Wolters, Dirk
AU  - Wolters D
FAU - Spindeldreher, Sebastian
AU  - Spindeldreher S
FAU - Muller, Bernd
AU  - Muller B
FAU - Langen, Hanno
AU  - Langen H
FAU - Ploegh, Hidde
AU  - Ploegh H
FAU - Vogt, Anne B
AU  - Vogt AB
FAU - Kropshofer, Harald
AU  - Kropshofer H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20040822
PL  - United States
TA  - Nat Immunol
JT  - Nature immunology
JID - 100941354
RN  - 0 (Antigens, Differentiation, B-Lymphocyte)
RN  - 0 (Autoantigens)
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 0 (invariant chain)
SB  - IM
MH  - Antigen Presentation/immunology
MH  - Antigens, Differentiation, B-Lymphocyte/*immunology
MH  - Autoantigens/immunology
MH  - Chromatography, Liquid
MH  - Dendritic Cells/*immunology
MH  - Electrophoresis, Polyacrylamide Gel
MH  - Flow Cytometry
MH  - Histocompatibility Antigens Class II/*immunology
MH  - Humans
MH  - Immunoblotting
MH  - Lymphocyte Activation/*immunology
MH  - Mass Spectrometry
MH  - Microscopy, Confocal
MH  - Receptor Aggregation/*immunology
MH  - Spectrometry, Mass, Electrospray Ionization
MH  - Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
MH  - Th1 Cells/*immunology
MH  - Up-Regulation
EDAT- 2004/08/24 05:00
MHDA- 2004/10/01 05:00
CRDT- 2004/08/24 05:00
PHST- 2004/07/07 00:00 [received]
PHST- 2004/07/28 00:00 [accepted]
PHST- 2004/08/24 05:00 [pubmed]
PHST- 2004/10/01 05:00 [medline]
PHST- 2004/08/24 05:00 [entrez]
AID - ni1108 [pii]
AID - 10.1038/ni1108 [doi]
PST - ppublish
SO  - Nat Immunol. 2004 Sep;5(9):909-18. doi: 10.1038/ni1108. Epub 2004 Aug 22.