PMID- 15322566
OWN - NLM
STAT- MEDLINE
DCOM- 20050225
LR  - 20111117
IS  - 0268-3369 (Print)
IS  - 0268-3369 (Linking)
VI  - 34
IP  - 8
DP  - 2004 Oct
TI  - Expansion and activation of minor histocompatibility antigen HY-specific T cells 
      associated with graft-versus-leukemia response.
PG  - 703-9
AB  - The immune system of females is capable of recognizing and reacting against the 
      male-specific minor histocompatibility antigen (mHA), HY. Thus, cytotoxic 
      T-lymphocytes (CTLs) recognizing this antigen may be useful in eradicating 
      leukemic cells of a male patient if they can be generated in vivo or in vitro 
      from a human leukocyte antigen (HLA)-identical female donor. The 
      HLA-A*0201-restricted HY antigen, FIDSYICQV, is a male-specific mHA. Using 
      HLA-A2/HY peptide tetrameric complexes, we reveal a close association between the 
      emergence of HY peptide-specific CD8(+) T cells in peripheral blood and molecular 
      remission of relapsed BCR/ABL(+) chronic myelogenous leukemia in lymphoid blast 
      crisis in a patient who underwent female-to-male transplantation. Assessment of 
      intracellular cytokine levels identified T cells that produce interferon-gamma in 
      response to the HY peptide during the presence of HY tetramer-positive T cells. 
      These results indicate that transplant with allogeneic HY-specific CTLs has 
      therapeutic potential for relapsed leukemia, and that expansion of such T cells 
      may be involved in the development of a graft-versus-leukemia response against 
      lymphoblastic leukemia cells.
FAU - Takami, A
AU  - Takami A
AD  - Department of Cellular Transplantation Biology, Kanazawa University Graduate 
      School of Medicine, 13-1 Takaramachi, Kanazawa 920-8641, Japan. 
      takami@med3.m.kanazawa-u.ac.jp
FAU - Sugimori, C
AU  - Sugimori C
FAU - Feng, X
AU  - Feng X
FAU - Yachie, A
AU  - Yachie A
FAU - Kondo, Y
AU  - Kondo Y
FAU - Nishimura, R
AU  - Nishimura R
FAU - Kuzushima, K
AU  - Kuzushima K
FAU - Kotani, T
AU  - Kotani T
FAU - Asakura, H
AU  - Asakura H
FAU - Shiobara, S
AU  - Shiobara S
FAU - Nakao, S
AU  - Nakao S
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Bone Marrow Transplant
JT  - Bone marrow transplantation
JID - 8702459
RN  - 0 (Antigens)
RN  - 0 (Complementarity Determining Regions)
RN  - 0 (Cytokines)
RN  - 0 (DNA, Complementary)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-A*02:01 antigen)
RN  - 0 (HLA-A2 Antigen)
RN  - 0 (Minor Histocompatibility Antigens)
RN  - 0 (Peptides)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Adolescent
MH  - Antigens/chemistry
MH  - Blast Crisis
MH  - CD8-Positive T-Lymphocytes/immunology/metabolism
MH  - Cell Transplantation
MH  - Complementarity Determining Regions/chemistry
MH  - Cytokines/biosynthesis
MH  - DNA, Complementary/metabolism
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Flow Cytometry
MH  - *Graft vs Leukemia Effect
MH  - HLA-A Antigens/chemistry
MH  - HLA-A2 Antigen
MH  - Humans
MH  - Interferon-gamma/biosynthesis
MH  - Leukemia, Lymphoid/therapy
MH  - Leukemia, Myelogenous, Chronic, BCR-ABL Positive/metabolism
MH  - Male
MH  - Minor Histocompatibility Antigens/*chemistry/*immunology
MH  - Peptides/chemistry
MH  - Polymerase Chain Reaction
MH  - Sex Factors
MH  - T-Lymphocytes/*immunology/metabolism
EDAT- 2004/08/24 05:00
MHDA- 2005/02/26 09:00
CRDT- 2004/08/24 05:00
PHST- 2004/08/24 05:00 [pubmed]
PHST- 2005/02/26 09:00 [medline]
PHST- 2004/08/24 05:00 [entrez]
AID - 1704583 [pii]
AID - 10.1038/sj.bmt.1704583 [doi]
PST - ppublish
SO  - Bone Marrow Transplant. 2004 Oct;34(8):703-9. doi: 10.1038/sj.bmt.1704583.