PMID- 15325151
OWN - NLM
STAT- MEDLINE
DCOM- 20041018
LR  - 20151119
IS  - 0048-9697 (Print)
IS  - 0048-9697 (Linking)
VI  - 331
IP  - 1-3
DP  - 2004 Sep 20
TI  - The Human Health Effect Programme in Greenland, a review.
PG  - 215-31
AB  - The burden of persistent organic pollutants (POPs) in Arctic peoples has been 
      monitored for some years. In 1997, the Alta Declaration extended the mandate of 
      the Arctic Assessment and Monitoring Programme (AMAP) to cover assessment of the 
      combined effects of environmental stressors. The AMAP Phase I assessment report 
      (Assessment report: Arctic pollution issues. Arctic monitoring and assessment 
      programme (AMAP), Oslo Norway, xii+859 pp. Vol xii + 859 pp. Oslo, Norway, 1998) 
      gave an overview of the classical toxicology of contaminants. Only recently a 
      programme for measuring the potential biological effects of these contaminants 
      has been established: The AMAP Human Health Effect Monitoring Programme. Body 
      burden data alone are not enough to assess the health risks associated with 
      exposure to environmental contaminants in Arctic peoples. Furthermore, laboratory 
      studies of the effects of single chemicals or chemical mixtures in laboratory 
      animals and cell cultures cannot fully elucidate the human health risks. 
      Integration of epidemiological health research and effect-biomarker studies on 
      humans from exposed populations in the Arctic is needed in order to obtain 
      information about the real health risks resulting from exposure to the 
      accumulated mixtures of contaminants in the Arctic. The present text aims to give 
      a short account of background literature on known and suspected effects of 
      environmental chemicals on endocrine regulated processes with special emphasis on 
      Arctic conditions. Following the evaluation of existing knowledge, a survey of 
      the recently started Human Health Effect Biomarker Programme in Greenland is 
      given.
FAU - Bonefeld-Jorgensen, Eva Cecilie
AU  - Bonefeld-Jorgensen EC
AD  - Unit of Environmental Biotechnology, Department of Environmental and Occupational 
      Medicine, University of Aarhus, DK-8000 Aarhus, Denmark. ebj@mil.au.dk
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - Sci Total Environ
JT  - The Science of the total environment
JID - 0330500
RN  - 0 (Biomarkers)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Gonadal Steroid Hormones)
RN  - 0 (Insecticides)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Arctic Regions
MH  - Biomarkers/analysis
MH  - Body Burden
MH  - Endocrine System/drug effects
MH  - *Environmental Monitoring
MH  - Environmental Pollutants/*poisoning
MH  - Female
MH  - Gonadal Steroid Hormones/pharmacology
MH  - Greenland
MH  - Health Surveys
MH  - Humans
MH  - Insecticides/*poisoning
MH  - Male
MH  - Polychlorinated Biphenyls/*poisoning
MH  - *Public Health
MH  - Risk Assessment
RF  - 126
EDAT- 2004/08/25 05:00
MHDA- 2004/10/19 09:00
CRDT- 2004/08/25 05:00
PHST- 2004/03/23 00:00 [accepted]
PHST- 2004/08/25 05:00 [pubmed]
PHST- 2004/10/19 09:00 [medline]
PHST- 2004/08/25 05:00 [entrez]
AID - S0048-9697(04)00225-6 [pii]
AID - 10.1016/j.scitotenv.2004.03.030 [doi]
PST - ppublish
SO  - Sci Total Environ. 2004 Sep 20;331(1-3):215-31. doi: 
      10.1016/j.scitotenv.2004.03.030.