PMID- 15325224
OWN - NLM
STAT- MEDLINE
DCOM- 20041208
LR  - 20191210
IS  - 0018-506X (Print)
IS  - 0018-506X (Linking)
VI  - 46
IP  - 3
DP  - 2004 Sep
TI  - The nose knows who's who: chemosensory individuality and mate recognition in 
      mice.
PG  - 231-40
AB  - Individual recognition is an important component of behaviors, such as mate 
      choice and maternal bonding that are vital for reproductive success. This article 
      highlights recent developments in our understanding of the chemosensory cues and 
      the neural pathways involved in individuality discrimination in rodents. There 
      appear to be several types of chemosensory signal of individuality that are 
      influenced by the highly polymorphic families of major histocompatibility complex 
      (MHC) proteins or major urinary proteins (MUPs). Both have the capability of 
      binding small molecules and may influence the individual profile of these 
      chemosignals in biological fluids such as urine, skin secretions, or saliva. 
      Moreover, these proteins, or peptides associated with them, can be taken up into 
      the vomeronasal organ (VNO) where they can potentially interact directly with the 
      vomeronasal receptors. This is particularly interesting given the expression of 
      major histocompatibility complex Ib proteins by the V2R class of vomeronasal 
      receptor and the highly selective responses of accessory olfactory bulb (AOB) 
      mitral cells to strain identity. These findings are consistent with the role of 
      the vomeronasal system in mediating individual discrimination that allows mate 
      recognition in the context of the pregnancy block effect. This is hypothesized to 
      involve a selective increase in the inhibitory control of mitral cells in the 
      accessory olfactory bulb at the first level of processing of the vomeronasal 
      stimulus.
FAU - Brennan, Peter A
AU  - Brennan PA
AD  - Sub-Department of Animal Behaviour, University of Cambridge, Madingley, Cambridge 
      CB3 8AA, UK. pab23@cus.cam.ac.uk
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Horm Behav
JT  - Hormones and behavior
JID - 0217764
RN  - 0 (Receptors, Odorant)
SB  - IM
MH  - Animals
MH  - Chemoreceptor Cells/physiology
MH  - Discrimination Learning/*physiology
MH  - Embryo Implantation/physiology
MH  - Female
MH  - Individuality
MH  - Major Histocompatibility Complex/physiology
MH  - Male
MH  - Mice
MH  - Neurons, Afferent/physiology
MH  - Nose/cytology/physiology
MH  - Perception/physiology
MH  - Pregnancy
MH  - Pregnancy Maintenance/physiology
MH  - Pregnancy, Animal/*physiology
MH  - Receptors, Odorant/*physiology
MH  - Recognition, Psychology/*physiology
MH  - Sexual Behavior, Animal/*physiology
MH  - Smell/*physiology
MH  - Urine/physiology
MH  - Vomeronasal Organ/cytology/physiology
RF  - 90
EDAT- 2004/08/25 05:00
MHDA- 2004/12/16 09:00
CRDT- 2004/08/25 05:00
PHST- 2003/12/04 00:00 [received]
PHST- 2004/01/07 00:00 [revised]
PHST- 2004/01/09 00:00 [accepted]
PHST- 2004/08/25 05:00 [pubmed]
PHST- 2004/12/16 09:00 [medline]
PHST- 2004/08/25 05:00 [entrez]
AID - S0018506X04000972 [pii]
AID - 10.1016/j.yhbeh.2004.01.010 [doi]
PST - ppublish
SO  - Horm Behav. 2004 Sep;46(3):231-40. doi: 10.1016/j.yhbeh.2004.01.010.