PMID- 15325798
OWN - NLM
STAT- MEDLINE
DCOM- 20050211
LR  - 20061115
IS  - 0165-2478 (Print)
IS  - 0165-2478 (Linking)
VI  - 95
IP  - 1
DP  - 2004 Aug 15
TI  - Increased expression of IL-18 in cutaneous graft-versus-host disease.
PG  - 57-61
AB  - Interleukin-18 (IL-18) is an 18-kDa cytokine produced by lipopolysaccharide 
      (LPS)-activated macrophages or Kupffer cells. In addition, IL-18 is also produced 
      by many different types of cells and tissues, including epidermal keratinocytes, 
      the adrenal cortex, and the brain. IL-18 acts on the immune system to increase 
      IFN-gamma production from T and NK cells to enhance NK cell cytotoxicity and to 
      activate Th1 cell proliferation. It is considered that the tissue expression of 
      cytokines and cell adhesion molecules such as ICAM-1 are common in 
      graft-versus-host disease (GVHD). Recent evidence suggests that IL-18 is a 
      cytokine relevant in the pathogenesis of GVHD. Despite the potential importance 
      of IL-18 in GVHD, the distribution of IL-18 production in cutaneous GVHD has not 
      been fully investigated. In this study, the expression of IL-18 in the cutaneous 
      GVHD was investigated. Formalin-fixed, paraffin-embedded tissue sections were 
      obtained, and immunohistochemical analysis was performed to detect IL-18 and 
      ICAM-1 expression according to the acute and chronic GVHD. Immunohistochemical 
      analysis confirmed the enhanced IL-18 expression levels in the early stage (grade 
      1) of acute GVHD and the late stage (sclerodermoid) of chronic GVHD compared to 
      the other stages. In contrast, the ICAM-1 expression level was constant at all 
      stages. Our findings indicate that IL-18 is a significant pathogenic indicator in 
      cutaneous GVHD, and the tissue expression of IL-18 seems to be associated with 
      the pathogenesis of acute and chronic GVHD.
FAU - Park, Hyun Jeong
AU  - Park HJ
AD  - Department of Dermatology, St. Mary's Hospital, College of Medicine, The Catholic 
      University of Korea, Seoul, Korea.
FAU - Kim, Ji Eun
AU  - Kim JE
FAU - Lee, Jun Yong
AU  - Lee JY
FAU - Cho, Baik Kee
AU  - Cho BK
FAU - Lee, Wang Jae
AU  - Lee WJ
FAU - Kim, Taesng
AU  - Kim T
FAU - Yoon, Doyoung
AU  - Yoon D
FAU - Cho, Daeho
AU  - Cho D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Immunol Lett
JT  - Immunology letters
JID - 7910006
RN  - 0 (Interleukin-18)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
SB  - IM
MH  - Chronic Disease
MH  - Graft vs Host Disease/*immunology/pathology/prevention & control
MH  - Humans
MH  - Intercellular Adhesion Molecule-1/biosynthesis
MH  - Interleukin-18/*biosynthesis/metabolism
MH  - *Skin/pathology
MH  - Up-Regulation
EDAT- 2004/08/25 05:00
MHDA- 2005/02/12 09:00
CRDT- 2004/08/25 05:00
PHST- 2004/05/18 00:00 [received]
PHST- 2004/06/08 00:00 [revised]
PHST- 2004/06/10 00:00 [accepted]
PHST- 2004/08/25 05:00 [pubmed]
PHST- 2005/02/12 09:00 [medline]
PHST- 2004/08/25 05:00 [entrez]
AID - S0165-2478(04)00161-0 [pii]
AID - 10.1016/j.imlet.2004.06.011 [doi]
PST - ppublish
SO  - Immunol Lett. 2004 Aug 15;95(1):57-61. doi: 10.1016/j.imlet.2004.06.011.