PMID- 15327888
OWN - NLM
STAT- MEDLINE
DCOM- 20041104
LR  - 20161124
IS  - 0065-230X (Print)
IS  - 0065-230X (Linking)
VI  - 91
DP  - 2004
TI  - Prostate cancer and the met hepatocyte growth factor receptor.
PG  - 31-67
AB  - The hepatocyte growth factor/scatter factor (HGF/SF) and its receptor, the Met 
      protein tyrosine kinase, form a classic ligand-receptor system for 
      epithelial-mesenchymal communications in the normal and cancerous prostate. This 
      review illustrates the expression and activities of HGF/SF and Met during 
      prostate development, homeostasis, and carcinogenesis. The participation of 
      HGF/SF in the morphogenetic program of rodent prostate development, the role of 
      Met in normal human prostate epithelium, and underlying mechanisms of deregulated 
      Met expression in localized and metastatic prostate cancer are discussed. On the 
      basis of the commonly observed overexpression of Met in metastatic prostate 
      cancer, HGF/SF-Met-targeted imaging and therapeutic agents can now be applied 
      toward diagnosis and treatment.
FAU - Knudsen, Beatrice S
AU  - Knudsen BS
AD  - Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 
      Seattle, Washington 98125, USA.
FAU - Edlund, Magnus
AU  - Edlund M
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Adv Cancer Res
JT  - Advances in cancer research
JID - 0370416
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Proteoglycans)
RN  - 0 (Receptors, Androgen)
RN  - EC 2.7.10.1 (Proto-Oncogene Proteins c-met)
SB  - IM
MH  - Adenocarcinoma/diagnostic imaging/drug therapy/genetics/*metabolism/pathology
MH  - Adult
MH  - Animals
MH  - Antineoplastic Agents/pharmacology/therapeutic use
MH  - Cell Adhesion
MH  - Cell Differentiation
MH  - Dogs
MH  - Drug Design
MH  - Epithelial Cells/metabolism/pathology
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Male
MH  - Mice
MH  - Neoplasm Proteins/antagonists & inhibitors/*physiology
MH  - Prostatic Neoplasms/diagnostic imaging/drug 
      therapy/genetics/*metabolism/pathology
MH  - Proteoglycans/metabolism
MH  - Proto-Oncogene Proteins c-met/antagonists & inhibitors/*physiology
MH  - Radionuclide Imaging
MH  - Receptors, Androgen/metabolism
MH  - Signal Transduction
MH  - Stromal Cells/metabolism/pathology
RF  - 240
EDAT- 2004/08/26 05:00
MHDA- 2004/11/05 09:00
CRDT- 2004/08/26 05:00
PHST- 2004/08/26 05:00 [pubmed]
PHST- 2004/11/05 09:00 [medline]
PHST- 2004/08/26 05:00 [entrez]
AID - S0065230X04910020 [pii]
AID - 10.1016/S0065-230X(04)91002-0 [doi]
PST - ppublish
SO  - Adv Cancer Res. 2004;91:31-67. doi: 10.1016/S0065-230X(04)91002-0.