PMID- 15330128
OWN - NLM
STAT- MEDLINE
DCOM- 20041116
LR  - 20190906
IS  - 0393-2990 (Print)
IS  - 0393-2990 (Linking)
VI  - 19
IP  - 6
DP  - 2004
TI  - Phylogenetic analysis of hepatitis C virus isolates from Tunisian patients.
PG  - 555-62
AB  - There is little information on the epidemiology characterisation of HCV isolates 
      in Tunisia. Previous report showed predominance of genotype 1b. In this study, 32 
      HCV isolates from genotypes 1a (n = 10), 1b (n = 14), 2 (n = 4), 3a (n = 3) and 4 
      (n = 1) were genotyped by sequencing and phylogenetic analysis on the 
      non-structural 5b (NS5b) region. The isolates originated from 14 patients with 
      chronic hepatitis, 10 haemophiliacs and eight healthy blood donors. NS5b sequence 
      grouping was concordant with previous 5' untranslated region (5'UTR) genotyping 
      results in 91% of cases. Most of the Tunisian isolates were closely related to 
      the European ones, except for genotype 4 which seems to be related mostly to 
      isolates from Egypt. Isolates from genotype 1a obtained from haemophiliacs showed 
      distinct clustering and nucleic divergence from those obtained from 
      non-haemophiliac patients, this underlines the particular mode of contamination 
      of this group of patients.
FAU - Djebbi, Ahlem
AU  - Djebbi A
AD  - Laboratory of Clinical Virology, Institut Pasteur de Tunis, Tunisia.
FAU - Mejri, Selma
AU  - Mejri S
FAU - Thiers, Valerie
AU  - Thiers V
FAU - Triki, Henda
AU  - Triki H
LA  - eng
SI  - GENBANK/AF462275
SI  - GENBANK/AF462276
SI  - GENBANK/AF462277
SI  - GENBANK/AF462278
SI  - GENBANK/AF462279
SI  - GENBANK/AF462280
SI  - GENBANK/AF462281
SI  - GENBANK/AF462282
SI  - GENBANK/AF462283
SI  - GENBANK/AF462284
SI  - GENBANK/AF462285
SI  - GENBANK/AF462286
SI  - GENBANK/AF462287
SI  - GENBANK/AF462288
SI  - GENBANK/AF462289
SI  - GENBANK/AF462290
SI  - GENBANK/AF462291
SI  - GENBANK/AF462292
SI  - GENBANK/AF462293
SI  - GENBANK/AF462294
SI  - GENBANK/AF462295
SI  - GENBANK/AF462296
SI  - GENBANK/AF462297
SI  - GENBANK/AF462298
SI  - GENBANK/AF462299
SI  - GENBANK/AF462300
SI  - GENBANK/AF462301
SI  - GENBANK/AF462302
SI  - GENBANK/AF462303
SI  - GENBANK/AF462304
SI  - GENBANK/AF462305
SI  - GENBANK/AF462306
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Eur J Epidemiol
JT  - European journal of epidemiology
JID - 8508062
RN  - 0 (5' Untranslated Regions)
RN  - 0 (DNA, Viral)
SB  - IM
MH  - 5' Untranslated Regions/genetics
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Base Sequence
MH  - Case-Control Studies
MH  - DNA, Viral/analysis/chemistry
MH  - Female
MH  - Hemophilia A/classification/genetics
MH  - Hepacivirus/*classification/genetics
MH  - Hepatitis C/*epidemiology/genetics/*microbiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Molecular Sequence Data
MH  - *Phylogeny
MH  - Polymerase Chain Reaction
MH  - Tunisia/epidemiology
EDAT- 2004/08/28 05:00
MHDA- 2004/11/17 09:00
CRDT- 2004/08/28 05:00
PHST- 2004/08/28 05:00 [pubmed]
PHST- 2004/11/17 09:00 [medline]
PHST- 2004/08/28 05:00 [entrez]
AID - 10.1023/b:ejep.0000032348.83087.01 [doi]
PST - ppublish
SO  - Eur J Epidemiol. 2004;19(6):555-62. doi: 10.1023/b:ejep.0000032348.83087.01.