PMID- 1533042
OWN - NLM
STAT- MEDLINE
DCOM- 19920515
LR  - 20190501
IS  - 0027-8424 (Print)
IS  - 1091-6490 (Electronic)
IS  - 0027-8424 (Linking)
VI  - 89
IP  - 8
DP  - 1992 Apr 15
TI  - Dorsal-ventral patterning in Drosophila: DNA binding of snail protein to the 
      single-minded gene.
PG  - 3414-8
AB  - The Drosophila snail gene is required for proper mesodermal development. Genetic 
      studies suggest that it functions by repressing adjacent ectodermal gene 
      expression including that of the single-minded (sim) gene. The snail gene encodes 
      a protein with a zinc-finger motif, and here we report that the snail gene 
      product is a sequence-specific DNA binding protein. The snail protein recognizes 
      a 14-base-pair consensus sequence that is found nine times in a 2.8-kilobase sim 
      regulatory region. These results provide evidence for the direct control of sim 
      transcription by snail.
FAU - Kasai, Y
AU  - Kasai Y
AD  - Department of Biology, University of California, Los Angeles 90024.
FAU - Nambu, J R
AU  - Nambu JR
FAU - Lieberman, P M
AU  - Lieberman PM
FAU - Crews, S T
AU  - Crews ST
LA  - eng
GR  - R01 HD25251/HD/NICHD NIH HHS/United States
GR  - T 32 CA09056/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (Adenovirus Early Proteins)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Oligodeoxyribonucleotides)
RN  - 0 (Oncogene Proteins, Viral)
RN  - EC 3.2.1.23 (beta-Galactosidase)
SB  - IM
GS  - Sna
GS  - sim
MH  - Adenovirus Early Proteins
MH  - Alleles
MH  - Animals
MH  - Base Sequence
MH  - Blastoderm/physiology
MH  - DNA-Binding Proteins/*genetics/metabolism
MH  - Drosophila/embryology/*genetics
MH  - Embryo, Nonmammalian/physiology
MH  - *Genes
MH  - Molecular Sequence Data
MH  - Oligodeoxyribonucleotides
MH  - Oncogene Proteins, Viral/genetics
MH  - Promoter Regions, Genetic
MH  - Zinc Fingers/*genetics
MH  - beta-Galactosidase/genetics/metabolism
PMC - PMC48878
EDAT- 1992/04/15 00:00
MHDA- 1992/04/15 00:01
PMCR- 1992/10/15
CRDT- 1992/04/15 00:00
PHST- 1992/04/15 00:00 [pubmed]
PHST- 1992/04/15 00:01 [medline]
PHST- 1992/04/15 00:00 [entrez]
PHST- 1992/10/15 00:00 [pmc-release]
AID - 10.1073/pnas.89.8.3414 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 1992 Apr 15;89(8):3414-8. doi: 10.1073/pnas.89.8.3414.