PMID- 15331433
OWN - NLM
STAT- MEDLINE
DCOM- 20050531
LR  - 20130520
IS  - 1524-4636 (Electronic)
IS  - 1079-5642 (Linking)
VI  - 24
IP  - 11
DP  - 2004 Nov
TI  - Bone marrow-derived monocyte chemoattractant protein-1 receptor CCR2 is critical 
      in angiotensin II-induced acceleration of atherosclerosis and aneurysm formation 
      in hypercholesterolemic mice.
PG  - e174-8
AB  - Angiotensin II (Ang II) is implicated in atherogenesis by activating inflammatory 
      responses in arterial wall cells. Ang II accelerates the atherosclerotic process 
      in hyperlipidemic apoE-/- mice by recruiting and activating monocytes. Monocyte 
      chemoattractant protein-1 (MCP-1) controls monocyte-mediated inflammation through 
      its receptor, CCR2. The roles of leukocyte-derived CCR2 in the Ang II-induced 
      acceleration of the atherosclerotic process, however, are not known. We 
      hypothesized that deficiency of leukocyte-derived CCR2 suppresses Ang II-induced 
      atherosclerosis. METHODS AND RESULTS: A bone marrow transplantation technique 
      (BMT) was used to develop apoE-/- mice with and without deficiency of CCR2 in 
      leukocytes (BMT-apoE-/-CCR2+/+ and BMT-apoE-/-CCR2-/- mice). Compared with 
      BMT-apoE-/-CCR2+/+ mice, Ang II-induced increases in atherosclerosis plaque size 
      and abdominal aortic aneurysm formation were suppressed in BMT-apoE-/-CCR2-/- 
      mice. This suppression was associated with a marked decrease in monocyte-mediated 
      inflammation and inflammatory cytokine expression. CONCLUSIONS: Leukocyte-derived 
      CCR2 is critical in Ang II-induced atherosclerosis and abdominal aneurysm 
      formation. The present data suggest that vascular inflammation mediated by CCR2 
      in leukocytes is a reasonable target of therapy for treatment of atherosclerosis.
FAU - Ishibashi, Minako
AU  - Ishibashi M
AD  - Department of Cardiovascular Medicine, Graduate School of Medical Sciences, 
      Kyushu University, Fukuoka, Japan.
FAU - Egashira, Kensuke
AU  - Egashira K
FAU - Zhao, Qingwei
AU  - Zhao Q
FAU - Hiasa, Ken-ichi
AU  - Hiasa K
FAU - Ohtani, Kisho
AU  - Ohtani K
FAU - Ihara, Yoshiko
AU  - Ihara Y
FAU - Charo, Israel F
AU  - Charo IF
FAU - Kura, Shinobu
AU  - Kura S
FAU - Tsuzuki, Teruhisa
AU  - Tsuzuki T
FAU - Takeshita, Akira
AU  - Takeshita A
FAU - Sunagawa, Kenji
AU  - Sunagawa K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20040826
PL  - United States
TA  - Arterioscler Thromb Vasc Biol
JT  - Arteriosclerosis, thrombosis, and vascular biology
JID - 9505803
RN  - 0 (Apolipoproteins E)
RN  - 0 (Ccr2 protein, mouse)
RN  - 0 (Receptors, CCR2)
RN  - 0 (Receptors, Chemokine)
RN  - 11128-99-7 (Angiotensin II)
SB  - IM
MH  - Angiotensin II/*metabolism
MH  - Animals
MH  - Aortic Aneurysm, Abdominal/*etiology
MH  - Apolipoproteins E/deficiency
MH  - Arteriosclerosis/*pathology
MH  - Bone Marrow/*chemistry
MH  - Bone Marrow Transplantation/methods
MH  - Leukocytes/chemistry/metabolism
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Inbred Strains
MH  - Monocytes/chemistry/metabolism
MH  - Receptors, CCR2
MH  - Receptors, Chemokine/deficiency/*physiology
EDAT- 2004/08/28 05:00
MHDA- 2005/06/01 09:00
CRDT- 2004/08/28 05:00
PHST- 2004/08/28 05:00 [pubmed]
PHST- 2005/06/01 09:00 [medline]
PHST- 2004/08/28 05:00 [entrez]
AID - 01.ATV.0000143384.69170.2d [pii]
AID - 10.1161/01.ATV.0000143384.69170.2d [doi]
PST - ppublish
SO  - Arterioscler Thromb Vasc Biol. 2004 Nov;24(11):e174-8. doi: 
      10.1161/01.ATV.0000143384.69170.2d. Epub 2004 Aug 26.