PMID- 1533242
OWN - NLM
STAT- MEDLINE
DCOM- 19920526
LR  - 20220321
IS  - 0022-1007 (Print)
IS  - 1540-9538 (Electronic)
IS  - 0022-1007 (Linking)
VI  - 175
IP  - 5
DP  - 1992 May 1
TI  - Human epidermal Langerhans cells express the high affinity receptor for 
      immunoglobulin E (Fc epsilon RI).
PG  - 1285-90
AB  - It has been suggested that epidermal Langerhans cells (LC) bearing immunoglobulin 
      E (IgE) may be involved in the genesis of atopic disease. The identity of the IgE 
      receptor(s) on LC remained unclear, although it represents a crucial point in 
      understanding cellular events linked to the binding of allergens to LC via IgE. 
      In this report, we demonstrate that epidermal LC express the high affinity 
      receptor for the Fc fragment of IgE (Fc epsilon RI) which has, so far, only been 
      described on mast cells and basophils. Epidermal LC react with antibodies 
      specific for the alpha subunit of the tetrameric (alpha, beta, 2 gamma) Fc 
      epsilon RI. Specific transcripts for Fc epsilon RI alpha and Fc epsilon RI gamma 
      were detected in LC and correspond to those of human basophils and of the human 
      basophil cell line KU812. Furthermore, human basophils, KU812 cells, and LC 
      express the putative beta subunit. Thus human LC express the complete structure 
      of Fc epsilon RI. This finding opens new perspectives in the putative functional 
      role of this structure on antigen-presenting cells.
FAU - Bieber, T
AU  - Bieber T
AD  - Department of Dermatology, University of Munich Medical School, Germany.
FAU - de la Salle, H
AU  - de la Salle H
FAU - Wollenberg, A
AU  - Wollenberg A
FAU - Hakimi, J
AU  - Hakimi J
FAU - Chizzonite, R
AU  - Chizzonite R
FAU - Ring, J
AU  - Ring J
FAU - Hanau, D
AU  - Hanau D
FAU - de la Salle, C
AU  - de la Salle C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Exp Med
JT  - The Journal of experimental medicine
JID - 2985109R
RN  - 0 (Antigens, Differentiation, B-Lymphocyte)
RN  - 0 (Immunoglobulin Fc Fragments)
RN  - 0 (Receptors, Fc)
RN  - 0 (Receptors, IgE)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Amino Acid Sequence
MH  - Antigens, Differentiation, B-Lymphocyte/genetics/*metabolism
MH  - Base Sequence
MH  - Basophils/metabolism
MH  - Cell Line
MH  - Cells, Cultured
MH  - DNA
MH  - Humans
MH  - Immunoblotting
MH  - Immunoglobulin E/*metabolism
MH  - Immunoglobulin Fc Fragments/metabolism
MH  - Immunohistochemistry
MH  - Langerhans Cells/cytology/*metabolism
MH  - Molecular Sequence Data
MH  - Receptors, Fc/genetics/*metabolism
MH  - Receptors, IgE
MH  - Sequence Alignment
PMC - PMC2119213
EDAT- 1992/05/01 00:00
MHDA- 1992/05/01 00:01
PMCR- 1992/11/01
CRDT- 1992/05/01 00:00
PHST- 1992/05/01 00:00 [pubmed]
PHST- 1992/05/01 00:01 [medline]
PHST- 1992/05/01 00:00 [entrez]
PHST- 1992/11/01 00:00 [pmc-release]
AID - 92235608 [pii]
AID - 10.1084/jem.175.5.1285 [doi]
PST - ppublish
SO  - J Exp Med. 1992 May 1;175(5):1285-90. doi: 10.1084/jem.175.5.1285.