PMID- 15332627
OWN - NLM
STAT- MEDLINE
DCOM- 20041014
LR  - 20191210
IS  - 0957-4530 (Print)
IS  - 0957-4530 (Linking)
VI  - 15
IP  - 4
DP  - 2004 Apr
TI  - Rationalising the design of polymeric thermoresponsive biomaterials.
PG  - 513-7
AB  - We investigated the cell adhesion and growth of a series of thermoresponsive 
      copolymers of N-isopropylacrylamide (NIPA) and N-tert-butylacrylamide (NtBA) 
      above their lower critical solubility temperatures (LCST). It was found that cell 
      adhesion and growth on the solvent cast films improved with increasing the NtBA 
      content in the copolymers. The improvement was dependent on cell line. The 
      surfaces of copolymers were analysed by atomic force microscopy. The topography 
      of polymer films was not dependent on composition. The differences in the cell 
      attachment and growth were attributed to the variation of surface energy with 
      composition. The surface energy of copolymers decreased with the increase in the 
      NtBA content. We conclude that poly(N-isopropylacrylamide) (poly(NIPA)) is a 
      relatively poor substrate for cell growth and proliferation. However, its ability 
      to support cell growth can be significantly improved by suitable modification.
FAU - Rochev, Yu
AU  - Rochev Y
AD  - National Centre for Biomedical Engineering Science, National University of 
      Ireland, Galway, Ireland. rotchev@yahoo.com
FAU - O'Halloran, D
AU  - O'Halloran D
FAU - Gorelova, T
AU  - Gorelova T
FAU - Gilcreest, V
AU  - Gilcreest V
FAU - Selezneva, I
AU  - Selezneva I
FAU - Gavrilyuk, B
AU  - Gavrilyuk B
FAU - Gorelov, A
AU  - Gorelov A
LA  - eng
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
PL  - United States
TA  - J Mater Sci Mater Med
JT  - Journal of materials science. Materials in medicine
JID - 9013087
RN  - 0 (Acrylamides)
RN  - 0 (Biocompatible Materials)
RN  - 0 (Polymers)
RN  - 102667-59-4 (poly(N-isopropylacrylamide-N-tert-butylacrylamide)copolymer)
SB  - IM
MH  - Acrylamides/*chemistry
MH  - Animals
MH  - Biocompatible Materials/*chemistry/radiation effects
MH  - Cell Adhesion
MH  - Cell Culture Techniques/instrumentation/*methods
MH  - Cell Division
MH  - Cell Line
MH  - Cell Line, Tumor
MH  - Equipment Design
MH  - Fibroblasts/*cytology
MH  - *Hot Temperature
MH  - Humans
MH  - Laryngeal Neoplasms/*pathology
MH  - Materials Testing
MH  - Mice
MH  - Polymers/chemistry/radiation effects
MH  - Species Specificity
MH  - Statistics as Topic
MH  - Surface Properties
EDAT- 2004/08/31 05:00
MHDA- 2004/10/16 09:00
CRDT- 2004/08/31 05:00
PHST- 2004/08/31 05:00 [pubmed]
PHST- 2004/10/16 09:00 [medline]
PHST- 2004/08/31 05:00 [entrez]
AID - 10.1023/b:jmsm.0000021130.11711.16 [doi]
PST - ppublish
SO  - J Mater Sci Mater Med. 2004 Apr;15(4):513-7. doi: 
      10.1023/b:jmsm.0000021130.11711.16.