PMID- 15333034
OWN - NLM
STAT- MEDLINE
DCOM- 20050214
LR  - 20230829
IS  - 1538-7933 (Print)
IS  - 1538-7836 (Linking)
VI  - 2
IP  - 9
DP  - 2004 Sep
TI  - Correlation between thrombus regression and recurrent venous thromboembolism. 
      Examining venographic and clinical effects of low-molecular-weight heparins: a 
      meta-analysis.
PG  - 1581-7
AB  - We analyzed the correlation between thrombus regression on control venography 
      performed after discontinuation of heparin therapy and recurrent venous 
      thromboembolism (VTE) detected during clinical follow-up in randomized trials 
      comparing low-molecular-weight heparin (LMWH) and unfractionated heparin (UFH) in 
      patients with deep vein thrombosis (DVT). Data were abstracted from MEDLINE, 
      conference abstracts and reference lists of previous reviews. Randomized, 
      controlled trials comparing LMWH and UFH for the treatment of DVT using a 
      combined venographic and clinical assessment and with at least 2 months of 
      follow-up were selected. The proportions of patients with thrombus regression on 
      control venography performed soon after discontinuation of heparin therapy and 
      recurrent VTE at 2-6 months were independently collected by two researchers. 
      Thirteen studies met the inclusion criteria. There was a strong inverse 
      correlation between thrombus regression and recurrent VTE (r =- 0.70; P =0.008). 
      The venographic effect varied between the different LMWHs (P = 0.013). A very 
      strong correlation was found when the results were pooled by the type of LMWH 
      used (r = - 0.84; P=0.037). No influence of the dose interval used on the 
      venographic effect (P=0.156) or on recurrent VTE (P=0.218) was shown. The lack of 
      thrombus regression in venography, performed soon after heparin discontinuation, 
      was correlated with clinical recurrence. Non-invasive imaging techniques should 
      be relevant to identify non-responders and to assess the optimal duration of 
      initial heparin treatment in daily clinical practice.
FAU - Gomez-Outes, A
AU  - Gomez-Outes A
AD  - University Clinic of Navarra, School of Medicine, University of Navarra, 
      Pamplona, Spain. agomez@rovi.es
FAU - Lecumberri, R
AU  - Lecumberri R
FAU - Lafuente-Guijosa, A
AU  - Lafuente-Guijosa A
FAU - Martinez-Gonzalez, J
AU  - Martinez-Gonzalez J
FAU - Carrasco, P
AU  - Carrasco P
FAU - Rocha, E
AU  - Rocha E
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Thromb Haemost
JT  - Journal of thrombosis and haemostasis : JTH
JID - 101170508
RN  - 0 (Heparin, Low-Molecular-Weight)
SB  - IM
MH  - Heparin, Low-Molecular-Weight/administration & dosage/*therapeutic use
MH  - Humans
MH  - Phlebography
MH  - Randomized Controlled Trials as Topic
MH  - Recurrence
MH  - Thromboembolism/*etiology
MH  - Thrombosis/*drug therapy
MH  - Time Factors
MH  - Venous Thrombosis/*etiology
EDAT- 2004/08/31 05:00
MHDA- 2005/02/16 09:00
CRDT- 2004/08/31 05:00
PHST- 2004/08/31 05:00 [pubmed]
PHST- 2005/02/16 09:00 [medline]
PHST- 2004/08/31 05:00 [entrez]
AID - S1538-7836(22)18053-0 [pii]
AID - 10.1111/j.1538-7836.2004.00862.x [doi]
PST - ppublish
SO  - J Thromb Haemost. 2004 Sep;2(9):1581-7. doi: 10.1111/j.1538-7836.2004.00862.x.