PMID- 15334860
OWN - NLM
STAT- MEDLINE
DCOM- 20041104
LR  - 20190917
IS  - 0277-0008 (Print)
IS  - 0277-0008 (Linking)
VI  - 24
IP  - 8 Pt 2
DP  - 2004 Aug
TI  - Unfractionated heparin dosing nomograms: road maps to where?
PG  - 142S-145S
AB  - Weight-adjusted nomograms have been a significant advance in the use of 
      unfractionated heparin (UFH). Clinical trials have demonstrated the ability of 
      weight-adjusted nomograms to achieve a therapeutic activated partial 
      thromboplastin time (aPTT) more rapidly than with standard UFH dosing. Despite 
      this advantage, a significant number of patients have subtherapeutic and 
      supratherapeutic aPTTs. Real-world experiences also corroborate the inability to 
      keep UFH therapeutic with the use of nomograms. Despite the limitations of UFH 
      nomograms, they have been used in several different types of venous and arterial 
      thrombosis treatment settings. Unfortunately, these nomograms are not all 
      consistent and require a considerable amount of time for training health care 
      professionals on their use in order to limit the potential for medication errors. 
      Although UFH nomograms have provided advancement over standard UFH dosing, their 
      limitations still generate the desire for a more predictable anticoagulant.
FAU - Dobesh, Paul P
AU  - Dobesh PP
AD  - Division of Pharmacy Practice, St Louis College of Pharmacy, and the Department 
      of Pharmacy, St Luke's Hospital, St Louis, Missouri 63110, USA. 
      pdobesh@stlcop.edu
CN  - Heparin Consensus Group
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Pharmacotherapy
JT  - Pharmacotherapy
JID - 8111305
RN  - 0 (Fibrinolytic Agents)
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Body Weight
MH  - *Clinical Protocols
MH  - Clinical Trials as Topic
MH  - Fibrinolytic Agents/*administration & dosage
MH  - Heparin/*administration & dosage
MH  - Humans
MH  - Partial Thromboplastin Time
RF  - 11
EDAT- 2004/09/01 05:00
MHDA- 2004/11/05 09:00
CRDT- 2004/09/01 05:00
PHST- 2004/09/01 05:00 [pubmed]
PHST- 2004/11/05 09:00 [medline]
PHST- 2004/09/01 05:00 [entrez]
AID - 10.1592/phco.24.12.142s.36113 [doi]
PST - ppublish
SO  - Pharmacotherapy. 2004 Aug;24(8 Pt 2):142S-145S. doi: 
      10.1592/phco.24.12.142s.36113.