PMID- 15335457
OWN - NLM
STAT- MEDLINE
DCOM- 20041214
LR  - 20191108
IS  - 1526-8209 (Print)
IS  - 1526-8209 (Linking)
VI  - 5
IP  - 3
DP  - 2004 Aug
TI  - HER2 and central nervous system metastasis in patients with breast cancer.
PG  - 232-4
AB  - We report a case of a patient who developed a central nervous system (CNS) 
      metastasis 17 months after surgery and adjuvant therapy for stage II breast 
      cancer. The HER2 status of the primary tumor as determined by 
      immunohistochemistry (IHC) was 1+, and fluorescence in situ hybridization (FISH) 
      performed retrospectively showed a borderline-negative result (ratio, 1:9), 
      although HER2 amplification was present in a minority of breast cancer cells. By 
      contrast, the HER2 status of the CNS metastasis was positive by IHC (3+) and FISH 
      (ratio, 3:7). This report discusses the possibility that, for metastatic invasion 
      into the CNS, clonal selection may occur, favoring HER2-positive cell clones.
FAU - Montemurro, Filippo
AU  - Montemurro F
AD  - Medical Oncology, Institute for Cancer Research and Treatment, Candiolo, Torino, 
      Italy. fmontemurro@ircc.mauriziano.it
FAU - Sarotto, Ivana
AU  - Sarotto I
FAU - Casorzo, Laura
AU  - Casorzo L
FAU - Pisacane, Alberto
AU  - Pisacane A
FAU - Aglietta, Massimo
AU  - Aglietta M
FAU - De Rosa, Giovanni
AU  - De Rosa G
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Clin Breast Cancer
JT  - Clinical breast cancer
JID - 100898731
SB  - IM
MH  - Breast Neoplasms/*genetics/secondary
MH  - Carcinoma, Ductal, Breast/*genetics/pathology
MH  - Cerebellar Neoplasms/*genetics/secondary
MH  - Female
MH  - *Genes, erbB-2
MH  - Humans
MH  - Middle Aged
EDAT- 2004/09/01 05:00
MHDA- 2004/12/16 09:00
CRDT- 2004/09/01 05:00
PHST- 2004/09/01 05:00 [pubmed]
PHST- 2004/12/16 09:00 [medline]
PHST- 2004/09/01 05:00 [entrez]
AID - S1526-8209(11)70373-1 [pii]
AID - 10.3816/cbc.2004.n.027 [doi]
PST - ppublish
SO  - Clin Breast Cancer. 2004 Aug;5(3):232-4. doi: 10.3816/cbc.2004.n.027.