PMID- 15336304
OWN - NLM
STAT- MEDLINE
DCOM- 20041129
LR  - 20221207
IS  - 0924-977X (Print)
IS  - 0924-977X (Linking)
VI  - 14
IP  - 5
DP  - 2004 Oct
TI  - Intracerebroventricular injection of trazodone produces 5-HT receptor subtype 
      mediated anti-nociception at the supraspinal and spinal levels.
PG  - 419-24
AB  - Serotonin (5-HT) mediated anti-nociceptive effects induced by an anti-depressant, 
      trazodone, are related to 5-HT(1A) receptor activities at the supraspinal level. 
      5-HT(3) receptor activation via the descending anti-nociceptive pathways may 
      contribute to the trazodone mediated anti-nociception at the spinal level. 
      Intracerebroventricular (i.c.v.) injection of trazodone dose-dependently impaired 
      nociceptive responses in the formalin test in mice. Six and 15 microg of 
      trazodone inhibited the early (P<0.05 or 0.01) and the late phases of the 
      formalin test (P<0.05 or 0.01), while 3 microg had no effect. We examined the 
      effects of a selective 5-HT(1A) receptor antagonist, WAY-100635, a single 
      injection of which induced hyperalgesia (P<0.05), and blocked the 
      anti-nociceptive effects of trazodone (P<0.01) when the two were simultaneously 
      injected i.c.v. Intrathecal (i.t.) injection of a selective 5-HT(3) receptor 
      antagonist, 3-tropanylindole-3-carboxylate hydrochloride, blocked the 
      anti-nociceptive effects of i.c.v. trazodone (P<0.01), while WAY-100635 (i.t.) 
      did not impair trazodone mediated anti-nociception. Trazodone mediated 
      anti-nocicepton is related to serotonergic activity at both the supraspinal and 
      the spinal level.
FAU - Zhang, Rihui
AU  - Zhang R
AD  - Department of Physiology, Tokyo Women's Medical University, 8-1 Kawada-cho, 
      Shinjuku-ku, Tokyo 162-8666, Japan.
FAU - Nagata, Tomonari
AU  - Nagata T
FAU - Hayashi, Takayuki
AU  - Hayashi T
FAU - Miyata, Mariko
AU  - Miyata M
FAU - Kawakami, Yoriko
AU  - Kawakami Y
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Eur Neuropsychopharmacol
JT  - European neuropsychopharmacology : the journal of the European College of 
      Neuropsychopharmacology
JID - 9111390
RN  - 0 (Piperazines)
RN  - 0 (Pyridines)
RN  - 0 (Receptors, Serotonin)
RN  - 0 (Serotonin Antagonists)
RN  - 0 (Serotonin Uptake Inhibitors)
RN  - 71IH826FEG 
      (N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide)
RN  - YBK48BXK30 (Trazodone)
SB  - IM
MH  - Animals
MH  - Dose-Response Relationship, Drug
MH  - Drug Interactions
MH  - Injections, Intraventricular/methods
MH  - Injections, Spinal/methods
MH  - Male
MH  - Mice
MH  - Motor Activity/drug effects
MH  - Pain/chemically induced/*physiopathology
MH  - Pain Measurement/methods
MH  - Piperazines/pharmacology
MH  - Pyridines/pharmacology
MH  - Receptors, Serotonin/drug effects/*physiology
MH  - Serotonin Antagonists/pharmacology
MH  - Selective Serotonin Reuptake Inhibitors/*pharmacology
MH  - Spinal Cord/*drug effects/metabolism
MH  - Trazodone/*pharmacology
EDAT- 2004/09/01 05:00
MHDA- 2004/12/16 09:00
CRDT- 2004/09/01 05:00
PHST- 2003/10/07 00:00 [received]
PHST- 2003/12/18 00:00 [revised]
PHST- 2003/12/18 00:00 [accepted]
PHST- 2004/09/01 05:00 [pubmed]
PHST- 2004/12/16 09:00 [medline]
PHST- 2004/09/01 05:00 [entrez]
AID - S0924977X03002402 [pii]
AID - 10.1016/j.euroneuro.2003.12.006 [doi]
PST - ppublish
SO  - Eur Neuropsychopharmacol. 2004 Oct;14(5):419-24. doi: 
      10.1016/j.euroneuro.2003.12.006.