PMID- 15336786
OWN - NLM
STAT- MEDLINE
DCOM- 20041019
LR  - 20221207
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 65
IP  - 8
DP  - 2004 Aug
TI  - HLA DRB1* and DQB1* allelic diversity among Nadars: a primitive south Indian 
      Dravidian caste group.
PG  - 847-54
AB  - South India is one of the oldest geophysical regions occupied mainly by Dravidian 
      language-speaking people. In the present study, 84 unrelated healthy Nadar 
      individuals from Tamil Nadu State were analyzed for human leukocyte antigen (HLA) 
      DRB1* and DQB1* allele frequencies and their haplotype frequencies were analyzed 
      by high resolution polymerase chain reaction (PCR)-typing of genomic DNA. Results 
      revealed that Nadars possessed >0.1 allele frequencies of HLA DRB1*15011, 03, 04, 
      1404, 0701, 1001, and DQB1*0201, 03, 0501, and 0503. The highest frequencies of 
      DRB1*0317 (0.048), DRB1*1317 (0.012), and DRB1*1404 (0.107) in the world were 
      found among the Nadar caste. The most frequent two-locus haplotypes identified 
      among the Nadars were DRB1*0701-DQB1*0201 and DRB1*1000-DQB1*0501, and 
      DRB1*1404-DQB1*0503 and DRB1*15011-DQB1*0601. When compared with world 
      populations, HLA DRB1*1322, DRB1*1434, and DQB1*0614 were identified exclusively 
      among Nadars. The heterozygosity and Watterson's homozygosity tests indicated 
      that balancing selection still operates among the South Indian caste groups. The 
      hierarchical cluster analysis for DRB1 data from the Indian caste and population 
      groups showed that the Nadars cluster with Kashmir Brahmins and North Indians. 
      The present study shows that the Nadar caste has several unique alleles and 
      haplotypes at high frequency that are rare or absent in other populations of 
      India and the world.
FAU - Shankarkumar, Umapathy
AU  - Shankarkumar U
AD  - HLA Department, Institute of Immunohaematology (ICMR), K.E.M. Hospital, Parel, 
      Mumbai, India. shankarkumar16@hotmail.com
FAU - Sridharan, Balakrisnan
AU  - Sridharan B
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - DNA Fingerprinting
MH  - Ethnology
MH  - *Gene Frequency
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Haplotypes/genetics
MH  - Homozygote
MH  - Humans
MH  - India/ethnology
MH  - Social Class
MH  - White People/*genetics
EDAT- 2004/09/01 05:00
MHDA- 2004/10/20 09:00
CRDT- 2004/09/01 05:00
PHST- 2004/04/07 00:00 [received]
PHST- 2004/05/08 00:00 [revised]
PHST- 2004/05/19 00:00 [accepted]
PHST- 2004/09/01 05:00 [pubmed]
PHST- 2004/10/20 09:00 [medline]
PHST- 2004/09/01 05:00 [entrez]
AID - S0198-8859(04)00128-4 [pii]
AID - 10.1016/j.humimm.2004.05.011 [doi]
PST - ppublish
SO  - Hum Immunol. 2004 Aug;65(8):847-54. doi: 10.1016/j.humimm.2004.05.011.