PMID- 15336818
OWN - NLM
STAT- MEDLINE
DCOM- 20050203
LR  - 20061115
IS  - 0167-5273 (Print)
IS  - 0167-5273 (Linking)
VI  - 97
IP  - 1
DP  - 2004 Oct
TI  - Lack of regeneration of myocardium by autologous intracoronary mononuclear bone 
      marrow cell transplantation in humans with large anterior myocardial infarctions.
PG  - 123-7
AB  - BACKGROUND: Experimental and preliminary clinical data suggest that 
      transplantation of autologous bone marrow cells (BMC) may contribute to 
      regeneration of the myocardium after acute myocardial infarction. This approach 
      should be tested in patients with large infarctions in whom a positive effect 
      would be most beneficial. METHODS AND RESULTS: After successful recanalization 
      within 5.9 +/- 2.5 h and stent implantation in five patients with a large acute 
      anterior myocardial infarction (AMI), the patients received autologous 
      mononuclear BMCs via a balloon catheter placed into the left anterior descending 
      artery 6.3 +/- 0.4 days after revascularization. At 3-month follow-up, no 
      improvement was observed for left ventricular ejection fraction, regional wall 
      motion in the infarcted zone, contractility index measured via dobutamine stress 
      echocardiography, coronary blood flow reserve and maximal oxygen uptake, 
      respectively. After further follow-up of 12 months, again no change of the left 
      ventricular ejection fraction could be detected. CONCLUSIONS: Intracoronary 
      transplantation of autologous mononuclear BMCs did not improve cardiac function 
      in our patients with large anterior myocardial infarctions after 3 and 12 months.
CI  - Copyright 2004 Elsevier Ireland Ltd.
FAU - Kuethe, Friedhelm
AU  - Kuethe F
AD  - Klinik fuer Innere Medizin I, Friedrich-Schiller-Universitaet Jena, Erlanger 
      Allee 101, 07740 Jena, Germany. Friedhelm.Kuethe@med.uni-jena.de
FAU - Richartz, Barbara M
AU  - Richartz BM
FAU - Sayer, Herbert G
AU  - Sayer HG
FAU - Kasper, Christoph
AU  - Kasper C
FAU - Werner, Gerald S
AU  - Werner GS
FAU - Hoffken, Klaus
AU  - Hoffken K
FAU - Figulla, Hans R
AU  - Figulla HR
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Netherlands
TA  - Int J Cardiol
JT  - International journal of cardiology
JID - 8200291
SB  - IM
MH  - *Bone Marrow Transplantation
MH  - Coronary Vessels/*surgery
MH  - Female
MH  - Heart/physiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/pathology/*surgery
MH  - Regeneration
MH  - Time Factors
MH  - Treatment Failure
EDAT- 2004/09/01 05:00
MHDA- 2005/02/04 09:00
CRDT- 2004/09/01 05:00
PHST- 2004/02/16 00:00 [received]
PHST- 2004/05/05 00:00 [accepted]
PHST- 2004/09/01 05:00 [pubmed]
PHST- 2005/02/04 09:00 [medline]
PHST- 2004/09/01 05:00 [entrez]
AID - S0167-5273(04)00362-6 [pii]
AID - 10.1016/j.ijcard.2004.05.002 [doi]
PST - ppublish
SO  - Int J Cardiol. 2004 Oct;97(1):123-7. doi: 10.1016/j.ijcard.2004.05.002.