PMID- 15338487
OWN - NLM
STAT- MEDLINE
DCOM- 20041221
LR  - 20161124
IS  - 0315-162X (Print)
IS  - 0315-162X (Linking)
VI  - 31
IP  - 9
DP  - 2004 Sep
TI  - Connective tissue metabolism in patients with unclassified polyarthritis and 
      early rheumatoid arthritis. Relationship to disease activity, bone mineral 
      density, and radiographic outcome.
PG  - 1698-708
AB  - OBJECTIVE: To assess the applicability of serum concentrations of markers of 
      synovial inflammation, cartilage, and bone metabolism in relation to conventional 
      markers of disease activity, bone mineral density (BMD) of the hand, and 
      radiographic outcome. METHODS: Biochemical markers of collagen tissue metabolism 
      were measured in 72 patients with symmetrically swollen and tender second and 
      third metacarpophalangeal or proximal interphalangeal joints for at least 4 weeks 
      and less than 2 years. At 2 years, 51 patients fulfilled the American College 
      Rheumatology criteria for rheumatoid arthritis (RA) and 21 patients had 
      unclassified polyarthritis. Patients with RA were divided into groups according 
      to the mean disease activity and to magnetic resonance imaging and 
      radiographically detected bone erosions in the hands. RESULTS: Patients with RA 
      had significantly higher serum concentrations of matrix metalloproteinase-3 
      (MMP-3) at baseline and higher mean concentrations of serum MMP-3 and 
      pyridinoline (Pyd) during the first 6 and 12 months than patients with 
      unclassified polyarthritis. RA patients with persistent disease activity and 
      erosive disease had significantly higher concentrations of serum MMP-3 and Pyd 
      than patients with no disease activity or nonerosive disease. Significant mutual 
      correlations between serum MMP-3 and Pyd and C-reactive protein and erythrocyte 
      sedimentation rate were observed. The mean values of MMP-3 and Pyd correlated 
      significantly to the alpha coefficient of the digital x-ray radiogrammetry 
      (DXR-BMD). CONCLUSION: Serum MMP-3 and Pyd varied according to disease activity, 
      periarticular osteoporosis measured by DXR, and radiographic outcome, and thus 
      appear to supplement the conventional markers of disease activity for monitoring 
      patients with RA.
FAU - Jensen, Trine
AU  - Jensen T
AD  - Department of Rheumatology, H:S Hvidovre Hospital, University of Copenhagen, 
      Hvidovre, Denmark. twj@dadlnet.dk
FAU - Klarlund, Mette
AU  - Klarlund M
FAU - Hansen, Michael
AU  - Hansen M
FAU - Jensen, Karl Erik
AU  - Jensen KE
FAU - Skjodt, Henrik
AU  - Skjodt H
FAU - Hyldstrup, Lars
AU  - Hyldstrup L
CN  - Danisit TIRA Group
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Canada
TA  - J Rheumatol
JT  - The Journal of rheumatology
JID - 7501984
RN  - 0 (Biomarkers)
RN  - 0 (Collagen Type I)
RN  - 0 (Collagen Type II)
RN  - 0 (Peptide Fragments)
RN  - 0 (Procollagen)
RN  - 0 (procollagen Type I N-terminal peptide)
RN  - EC 3.4.24.- (Collagenases)
RN  - EC 3.4.24.- (MMP13 protein, human)
RN  - EC 3.4.24.- (Matrix Metalloproteinase 13)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
RN  - EC 3.4.24.7 (Matrix Metalloproteinase 1)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Arthritis, Rheumatoid/*diagnostic imaging/immunology/*metabolism
MH  - Biomarkers
MH  - *Bone Density
MH  - Bone and Bones/immunology/metabolism
MH  - Cartilage/immunology/metabolism
MH  - Collagen Type I/metabolism
MH  - Collagen Type II/metabolism
MH  - Collagenases/blood
MH  - Connective Tissue/immunology/*metabolism
MH  - Female
MH  - Humans
MH  - Male
MH  - Matrix Metalloproteinase 1/blood
MH  - Matrix Metalloproteinase 13
MH  - Matrix Metalloproteinase 3/blood
MH  - Middle Aged
MH  - Peptide Fragments/blood
MH  - Procollagen/blood
MH  - Radiography
MH  - Severity of Illness Index
MH  - Synovial Membrane/immunology/metabolism
EDAT- 2004/09/01 05:00
MHDA- 2004/12/22 09:00
CRDT- 2004/09/01 05:00
PHST- 2004/09/01 05:00 [pubmed]
PHST- 2004/12/22 09:00 [medline]
PHST- 2004/09/01 05:00 [entrez]
AID - 0315162X-31-1698 [pii]
PST - ppublish
SO  - J Rheumatol. 2004 Sep;31(9):1698-708.