PMID- 1533947
OWN - NLM
STAT- MEDLINE
DCOM- 19920612
LR  - 20041117
IS  - 0567-7556 (Print)
IS  - 0567-7556 (Linking)
VI  - 42
DP  - 1992
TI  - Ultrastructure and biosynthetic activity of polyploid atrial myocytes in patients 
      with mitral valve disease.
PG  - 293-9
AB  - Biopsies of right auricle of human heart have been obtained during open heart 
      surgery from 6 patients aged 23 to 49. The DNA and total protein content have 
      been determined in isolated myocytes by two-wavelength scanning cytophotometry 
      after double staining: Feulgen and naphthol yellow S. In all the biopsies 
      predominant are polyploid hypertrophied myocytes. Both hypertrophied 
      non-degenerating cells and cells with different extent of degenerative changes, 
      primarily of myofibrils and membranes, are present. The highest extent of cell 
      ploidy is in patients belonging to functional class IV according to the 
      classification of New York Heart Association (NYHA); in these cases 72 to 98% of 
      cells have nuclei with 8 c and more DNA content. With an increase in ploidy 
      level, cells grow in size and in protein content, however the rate of this growth 
      is much lower than that of DNA content in cells. There is no direct relation 
      between ploidy and cell degeneration extent and no inverse relation between 
      degeneration extent and ejection fraction.
FAU - Erokhina, I L
AU  - Erokhina IL
AD  - Institute of Cytology, Academy of Sciences, Leningrad, USSR.
FAU - Selivanova, G V
AU  - Selivanova GV
FAU - Vlasova, T D
AU  - Vlasova TD
FAU - Komarova, N I
AU  - Komarova NI
FAU - Emeljanova, O I
AU  - Emeljanova OI
FAU - Soroka, V V
AU  - Soroka VV
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Acta Histochem Suppl
JT  - Acta histochemica. Supplementband
JID - 0061372
RN  - 0 (Muscle Proteins)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Adult
MH  - Cardiomegaly/pathology
MH  - DNA/metabolism
MH  - Female
MH  - Heart Valve Diseases/metabolism/pathology
MH  - Histocytochemistry
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Mitral Valve/*metabolism/pathology/ultrastructure
MH  - Muscle Proteins/metabolism
MH  - Myocardium/*metabolism/ultrastructure
EDAT- 1992/01/01 00:00
MHDA- 1992/01/01 00:01
CRDT- 1992/01/01 00:00
PHST- 1992/01/01 00:00 [pubmed]
PHST- 1992/01/01 00:01 [medline]
PHST- 1992/01/01 00:00 [entrez]
PST - ppublish
SO  - Acta Histochem Suppl. 1992;42:293-9.