PMID- 15339608
OWN - NLM
STAT- MEDLINE
DCOM- 20120402
LR  - 20190922
IS  - 1672-1977 (Print)
IS  - 1672-1977 (Linking)
VI  - 1
IP  - 1
DP  - 2003 May
TI  - [Clinical observation of the curative effect of Qiangxin Mixture on congestive 
      heart failure].
PG  - 25-9
AB  - OBJECTIVE: To investigate the efficacy of Qiangxin Mixture in patients with 
      congestive heart failure (CHF). METHODS: Sixty cases of CHF were randomly divided 
      into Qiangxin Mixture group (treatment group, n=30) and digoxin group (control 
      group, n=30). The total clinical effective rate, integra of the symptoms of 
      kidney deficiency, classification of functional capacity of the New York Heart 
      Association (NYHA), and echocardiogram [ejection fraction (EF), cardiac output 
      (CO), interventricular septal thickness (IVST), posterior wall thickness (PWT), 
      left ventricular mass index (LVMI)] as well as the measurement of plasma 
      endothelin, angiotensin II and atrial natriuretic peptide were observed in both 
      groups. RESULTS: The total clinical effective rate of Qiangxin Mixture group was 
      87%, and improvement was significantly observed in the Lee CHF score, 
      classification of functional capacity of the NYHA, EF and CO (P<0.05, vs before 
      treatment), but no significant improvement in digoxin group (P>0.05). The integra 
      of the symptoms of kidney deficiency, the levels of plasma ET, Ang II and ANP 
      decreased significantly (P<0.01, vs before treatment and digoxin group 
      respectively). IVST, PWT and LVMI were also reduced significantly (P<0.01, vs 
      before treatment; P<0.05 vs digoxin group). CONCLUSION: The Qiangxin Mixture is 
      effective in enhancing cardiac contraction, improving hemodynamics in the 
      short-term and rectifying some indexes in the long-term, so it could postpone the 
      processes of CHF. This mechanism may be related to decreasing the stimulating 
      factors (angiotensin, endothelin) which trigger the cardiac remodeling, delaying 
      or reversing the cardiac remodeling.
FAU - Chen, Zhao-Shan
AU  - Chen ZS
AD  - Department of Cardiovasology, Shanghai Hospital of Traditional Chinese Medicine, 
      Shanghai 200071, China. czshan@citiz.net
FAU - Dong, Yao-Rong
AU  - Dong YR
FAU - Hu, Wan-Ying
AU  - Hu WY
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - China
TA  - Zhong Xi Yi Jie He Xue Bao
JT  - Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine
JID - 101199657
RN  - 0 (Drug Combinations)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (qiangxin)
SB  - IM
MH  - Aged
MH  - Drug Combinations
MH  - Drugs, Chinese Herbal/*therapeutic use
MH  - Female
MH  - Heart Failure/*drug therapy
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Phytotherapy
MH  - Prognosis
EDAT- 2004/09/02 05:00
MHDA- 2012/04/03 06:00
CRDT- 2004/09/02 05:00
PHST- 2004/09/02 05:00 [pubmed]
PHST- 2012/04/03 06:00 [medline]
PHST- 2004/09/02 05:00 [entrez]
AID - 128 [pii]
AID - 10.3736/jcim20030111 [doi]
PST - ppublish
SO  - Zhong Xi Yi Jie He Xue Bao. 2003 May;1(1):25-9. doi: 10.3736/jcim20030111.