PMID- 15339774
OWN - NLM
STAT- MEDLINE
DCOM- 20041202
LR  - 20091026
IS  - 0029-7844 (Print)
IS  - 0029-7844 (Linking)
VI  - 104
IP  - 3
DP  - 2004 Sep
TI  - Transmission of parentally shared human leukocyte antigen alleles and the risk of 
      preterm delivery.
PG  - 594-600
AB  - OBJECTIVE: Our objective was to examine our hypothesis that the transmission of 
      parentally shared human leukocyte antigen (HLA) alleles to offspring increases 
      the risk of preterm delivery. METHODS: A population-based family study with 
      participating children and their parents was conducted in Kaiser Permanente 
      Medical Care Program, an integrated healthcare delivery system, in the Northern 
      California Region. A total of 234 participants from 78 families with early 
      preterm deliveries (35 weeks of gestation or greater) and 60 participants from 20 
      families with full-term births were included in the study. Buccal cells were 
      collected from the first-born preterm cases and their parents to determine HLA-B 
      (class I) and DRB1 (class II) types and the transmission of parental alleles to 
      the offspring. The buccal samples were also collected from full-term deliveries 
      to rule out possible segregation distortion at the studied HLA loci. RESULTS: 
      Compared with the expected transmission probability based on Mendel's laws (25%), 
      transmission of parentally shared HLA-B or DRB1 alleles from both heterozygous 
      parents to offspring (48% of 23 heterozygous parents) was associated with a more 
      than 5-fold increased risk of preterm delivery (odds ratio 5.5; 95% confidence 
      interval 1.2-51). Transmission of parentally shared HLA alleles from heterozygous 
      mothers (83%) appears to be more important in the etiology of preterm delivery 
      than transmission from fathers (57%). The transmission pattern of parentally 
      shared HLA alleles in our full-term controls was almost identical to the expected 
      pattern based on Mendel's laws and demonstrated no segregation distortion at 
      those HLA loci. CONCLUSION: Our findings provide evidence that the transmission 
      of parentally shared HLA alleles may be an underlying mechanism for preterm 
      delivery.
FAU - Li, De-Kun
AU  - Li DK
AD  - Division of Research, Kaiser Permanente, Oakland, California 94612, USA. 
      dkl@dor.kaiser.org
FAU - Odouli, Roxana
AU  - Odouli R
FAU - Liu, Liyan
AU  - Liu L
FAU - Vinson, Margaret
AU  - Vinson M
FAU - Trachtenberg, Elizabeth
AU  - Trachtenberg E
LA  - eng
GR  - 2 M01 RR01271-21/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Obstet Gynecol
JT  - Obstetrics and gynecology
JID - 0401101
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Alleles
MH  - Female
MH  - HLA Antigens/*immunology
MH  - Humans
MH  - *Maternal-Fetal Exchange
MH  - Obstetric Labor, Premature/*immunology
MH  - Pregnancy
MH  - Risk Factors
EDAT- 2004/09/02 05:00
MHDA- 2004/12/16 09:00
CRDT- 2004/09/02 05:00
PHST- 2004/09/02 05:00 [pubmed]
PHST- 2004/12/16 09:00 [medline]
PHST- 2004/09/02 05:00 [entrez]
AID - 104/3/594 [pii]
AID - 10.1097/01.AOG.0000130067.27022.1d [doi]
PST - ppublish
SO  - Obstet Gynecol. 2004 Sep;104(3):594-600. doi: 10.1097/01.AOG.0000130067.27022.1d.