PMID- 15339875
OWN - NLM
STAT- MEDLINE
DCOM- 20041019
LR  - 20220316
IS  - 1524-4539 (Electronic)
IS  - 0009-7322 (Linking)
VI  - 110
IP  - 9 Suppl 1
DP  - 2004 Aug 31
TI  - Initial treatment of venous thromboembolism.
PG  - I3-9
AB  - Adequate initial anticoagulant therapy of deep venous thrombosis (DVT) is 
      required to prevent thrombus growth and pulmonary embolism (PE). Intravenous 
      unfractionated heparin (UFH) is being replaced by low-molecular-weight heparin 
      (LMWH) as the anticoagulant of choice for initial treatment of venous 
      thromboembolism (VTE). Both agents are relatively safe and effective when used to 
      treat VTE, with LMWH suitable for outpatient therapy because of improved 
      bioavailability and more predictable anticoagulant response. Serious potential 
      complications of heparin therapy, such as heparin-induced thrombocytopenia (HIT) 
      and osteoporosis, seem less common with LMWH. The potential for fetal harm and 
      changes in maternal physiology complicate the treatment of VTE during pregnancy. 
      Although systemic thrombolysis is used in patients with massive PE and in some 
      patients with proximal DVT, controversy persists with respect to appropriate 
      patient selection for this intervention.
FAU - McRae, Simon J
AU  - McRae SJ
AD  - Department of Medicine, McMaster University, Hamilton, Ontario, Canada. 
      smcrae@mcmaster.ca
FAU - Ginsberg, Jeffrey S
AU  - Ginsberg JS
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Circulation
JT  - Circulation
JID - 0147763
RN  - 0 (Anticoagulants)
RN  - 0 (Fibrinolytic Agents)
SB  - IM
EIN - Circulation. 2004 Dec 14;110(24 Suppl 1):IV33
EIN - Circulation. 2005 Jan 25;111(3):378
MH  - Administration, Oral
MH  - Anticoagulants/administration & dosage/adverse effects/therapeutic use
MH  - Female
MH  - Fibrinolytic Agents/therapeutic use
MH  - Humans
MH  - Pregnancy
MH  - Pregnancy Complications, Cardiovascular/drug therapy
MH  - Pulmonary Embolism/*prevention & control
MH  - Thromboembolism/drug therapy
MH  - Thrombolytic Therapy
MH  - Venous Thrombosis/*drug therapy/therapy
RF  - 67
EDAT- 2004/09/02 05:00
MHDA- 2004/10/20 09:00
CRDT- 2004/09/02 05:00
PHST- 2004/09/02 05:00 [pubmed]
PHST- 2004/10/20 09:00 [medline]
PHST- 2004/09/02 05:00 [entrez]
AID - 110/9_suppl_1/I-3 [pii]
AID - 10.1161/01.CIR.0000140904.52752.0c [doi]
PST - ppublish
SO  - Circulation. 2004 Aug 31;110(9 Suppl 1):I3-9. doi: 
      10.1161/01.CIR.0000140904.52752.0c.